Randomized trial of a clinic-based weight loss intervention in cancer survivors

Journal of Cancer Survivorship : Research and Practice
Justin C BrownJennifer A Ligibel

Abstract

This trial examined the efficacy of a clinic-based weight loss intervention in cancer survivors. This single-center phase II trial randomized survivors of solid tumors and hematologic malignancies to a 15-week group-based weight loss intervention that included caloric restriction and physical activity (n = 30) or a wait-list control intervention (n = 30). The primary study outcome was body mass. Secondary study outcomes included body composition using dual-energy X-ray absorptiometry, physical fitness using the 6-min walk test (6MWT), and concentrations of serum biomarkers. Participants in the intervention group lost 5.6 ± 4.4% of baseline weight (4.6 ± 3.9 kg), whereas participants in the control group gained 0.2 ± 2.4% of baseline weight (0.2 ± 2.0 kg); intervention effect - 5.8% (95% CI - 7.8, - 3.8); - 4.8 kg (95% CI - 6.6, - 3.0); P = 0.0001. A larger proportion of participants in the intervention group lost ≥ 5% of baseline weight compared to the control group (43 vs 0%; P < 0.0001). The intervention led to reductions in fat mass (- 3.2 ± 0.7 kg; P < 0.0001), improvements in physical fitness (an increase of 22.6 ± 10.8 m on 6MWT; P = 0.03), and reductions in concentrations of insulin (- 7.7 ± 3.5 μU/mL; P = 0.004) and lep...Continue Reading

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Citations

Nov 23, 2019·The Cochrane Database of Systematic Reviews·Sorrel BurdenChris Todd
May 18, 2019·American Society of Clinical Oncology Educational Book·Jennifer A LigibelJennifer W Bea
Jan 15, 2019·Journal of Cachexia, Sarcopenia and Muscle·Justin C BrownBette J Caan
Oct 13, 2020·Journal of Medical Internet Research·Mickael RingevalSpyros Kitsiou

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