Randomized trial of botulinum toxin injections into the salivary glands to reduce drooling in children with neurological disorders

Developmental Medicine and Child Neurology
Susan M ReidDinah Reddihough

Abstract

The primary aim of this randomized, controlled trial was to assess the effectiveness of botulinum toxin A (BoNT-A) injections into the submandibular and parotid glands on drooling in children with cerebral palsy (CP) and other neurological disorders. Secondary aims were to ascertain the duration of any such effect and the timing of maximal response. Of the 48 participants (27 males, 21 females; mean age 11y 4mo [SD 3y 3mo], range 6-18y), 31 had a diagnosis of CP and 15 had a primary intellectual disability; 27 children were non-ambulant. Twenty-four children randomized to the treatment group received 25 units of BoNT-A into each parotid and submandibular gland. Those randomized to the control group received no treatment. The degree and impact of drooling was assessed by carers using the Drooling Impact Scale questionnaire at baseline and at monthly intervals up to 6 months postinjection/baseline, and again at 1 year. Maximal response was at 1 month at which time there was a highly significant difference in the mean scores between the groups. This difference remained statistically significant at 6 months. Four children failed to respond to the injections, four had mediocre results, and 16 had good results. While the use of BoNT-...Continue Reading

References

Jun 1, 1987·Developmental Medicine and Child Neurology·K Sonnander
Mar 1, 1974·Acta Oto-laryngologica·C Ekedahl
Nov 1, 1995·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·K B HallettR K Hall
Jun 1, 1997·Journal of Pediatric Psychology·J SquiresL Potter
Dec 31, 1997·Journal of Child Psychology and Psychiatry, and Allied Disciplines·N BottingN Marlow
Dec 16, 1998·Developmental Medicine and Child Neurology·N BottingN Marlow
Aug 10, 2000·The New England Journal of Medicine·N S WoodA R Wilkinson
Aug 23, 2000·Neurology·J D O'SullivanA J Lees
May 1, 2001·Journal of Paediatrics and Child Health·C Y SkellernM J O'Callaghan
Aug 6, 2002·Pediatric Neurology·J E BothwellP R Camfield
Aug 10, 2002·JAMA : the Journal of the American Medical Association·Adnan T BhuttaK J S Anand
Nov 28, 2002·Mental Retardation and Developmental Disabilities Research Reviews·Glen P Aylward
Feb 21, 2004·Developmental Medicine and Child Neurology·Hilary M JohnsonDinah S Reddihough
Mar 17, 2004·American Journal of Physical Medicine & Rehabilitation·Robert SavareseScott R Millis
Apr 23, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·N Marlow
Jun 4, 2004·Developmental Medicine and Child Neurology·Samantha JohnsonJane Schulte
Jul 15, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Oded HershkovichRafael M Nagler
Sep 3, 2004·Pediatrics·Peter H JongeriusJan J Rotteveel
Oct 27, 2004·Neurology·P H JongeriusF J A van den Hoogen
Mar 30, 2005·Journal of Child Neurology·Sharon Hassin-BaerBruria Ben-Zeev
Sep 15, 2005·Mental Retardation and Developmental Disabilities Research Reviews·Frances Page Glascoe
Oct 12, 2005·Plastic and Reconstructive Surgery·Andrew L GreensmithDinah S Reddihough
Dec 14, 2005·Journal of Developmental and Behavioral Pediatrics : JDBP·Glen P Aylward
Aug 17, 2006·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·M LimG Sandhu
Oct 19, 2006·Developmental Medicine and Child Neurology·K J BanerjeeS J O'Flaherty

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Citations

Jul 17, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·D ReddihoughUNKNOWN Cereral Palsy Institute
Jun 17, 2014·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Mélanie PorteIsabelle Laffont
Jan 23, 2016·BMC Pregnancy and Childbirth·Peter Brocklehurst, UNKNOWN INFANT Collaborative Group
Mar 19, 2013·Infant Behavior & Development·Maryhan BakerShelley Bartlett
May 15, 2012·Journal of Communication Disorders·Maja CepanecSanja Simleša
Oct 11, 2015·Seminars in Fetal & Neonatal Medicine·Jochen Profit, Roger F Soll
Feb 12, 2011·Genes, Brain, and Behavior·A J O WhitehouseS E Fisher
Mar 31, 2012·Developmental Medicine and Child Neurology·Tamanna MooreNeil Marlow
Jul 13, 2011·Developmental Medicine and Child Neurology·Gehan RobertsUNKNOWN Victorian Infant Collaborative Study Group
Feb 5, 2013·Paediatric and Perinatal Epidemiology·Mandy B BelfortMarie C McCormick
Dec 23, 2011·Developmental Medicine and Child Neurology·Andrew J MartinUNKNOWN Inis Trial Collaborative Group
Mar 29, 2012·Acta Paediatrica·Anne-Marie GuerrotUNKNOWN Perinatal Network of Haute-Normandie
Jun 16, 2010·Journal of Paediatrics and Child Health·Anna Maria Dall'OglioPatrizio Pasqualetti
Jul 26, 2015·Research in Developmental Disabilities·Einar Gudmundsson
Sep 16, 2015·Trials·Lucy E BradshawUNKNOWN Cord Pilot Trial Collaborative Group
Sep 25, 2014·Developmental Medicine and Child Neurology·Graham SchaferRos Jefferson
Apr 3, 2015·Archives of Disease in Childhood. Fetal and Neonatal Edition·Samantha JohnsonElaine M Boyle
Jan 22, 2015·Archives of Disease in Childhood. Fetal and Neonatal Edition·Shalin A ParekhEdmund Juszczak
Feb 7, 2015·PloS One·Lénaïg Abily-DonvalUNKNOWN Perinatal Network of Haute-Normandie
Oct 16, 2015·Archives of Disease in Childhood. Fetal and Neonatal Edition·David FieldElizabeth S Draper
Apr 21, 2010·BMC Pediatrics·David J FieldUNKNOWN NEST Study Group
Jun 19, 2013·JPEN. Journal of Parenteral and Enteral Nutrition·Deepika NehraMark Puder
Feb 14, 2018·Health Technology Assessment : HTA·Peter BrocklehurstOliver Rivero-Arias
Dec 1, 2012·Educational Researcher : a Publication of the American Educational Research Association·Paul L MorganSteve Maczuga
Sep 12, 2014·The Cochrane Database of Systematic Reviews·Emma MolyneauxKylee Trevillion
Oct 29, 2017·Archives of Disease in Childhood. Fetal and Neonatal Edition·Hilary S WongUNKNOWN Medicines for Neonates Investigator Group
Nov 19, 2015·American Journal of Speech-language Pathology·Paul L MorganStephanie Morano
Oct 10, 2019·The New England Journal of Medicine·Jon DorlingUNKNOWN SIFT Investigators Group
Apr 29, 2020·Health Technology Assessment : HTA·Jon DorlingEdmund Juszczak
Nov 7, 2019·Archives of Disease in Childhood. Fetal and Neonatal Edition·Elizabeth S DraperUNKNOWN EPICE group
Feb 8, 2020·International Journal of Epidemiology·Jennifer ZeitlinUNKNOWN EPICE and SHIPS Research Group
Feb 17, 2021·Seminars in Fetal & Neonatal Medicine·Jonathan S Litt, Susan R Hintz
Dec 12, 2012·European Journal of Pediatrics·Gitta ReunerJoachim Pietz
Oct 16, 2015·Journal of Developmental and Behavioral Pediatrics : JDBP·Samantha JohnsonElaine M Boyle
Jan 29, 2017·BMC Pediatrics·Jane AbbottUNKNOWN Sift Investigators Group
Jul 11, 2013·Archives of Disease in Childhood. Fetal and Neonatal Edition·Neil Marlow
Mar 31, 2012·Developmental Medicine and Child Neurology·Samantha JohnsonDieter Wolke
Jan 1, 2016·The American Journal of Clinical Nutrition·Samantha JohnsonElaine M Boyle

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