PMID: 11919241Mar 29, 2002Paper

Randomized trial of cisplatin and ifosfamide with or without bleomycin in squamous carcinoma of the cervix: a gynecologic oncology group study

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Jeffrey D BlossJo Benda

Abstract

Phase II trial reports have suggested that the addition of bleomycin to the combination of cisplatin and ifosfamide may improve response rates and possible survival in squamous carcinoma of the cervix. This study prospectively evaluates the combination of bleomycin to this regimen in women with histologically proven advanced recurrent or persistent squamous cell carcinoma of the cervix. Eligible women were randomized to receive either cisplatin (50 mg/m(2)), ifosfamide (5 g/m(2) over 24 hours), and mesna (6 g/m(2) during ifosfamide infusion and the following 12 hours) (CI) versus bleomycin 30 units over 24 hours on day 1 followed by cisplatin (50 mg/m(2)), ifosfamide (5 g/m(2) over 24 hours), and mesna (6 g/m(2) during ifosfamide infusion and the following 12 hours) (CIB). Three hundred three women were enrolled onto this trial, of which 287 were assessable. There were no significant differences between CI and CIB with regard to response rates (32% v 31.2%, respectively), progression-free survival (PFS), or overall survival. PFS and survival were associated with initial performance status (PS). Patients with a PS of 0 experienced a lower rate of failure (P =.013) and a lower risk of death (P =.009) compared with patients with P...Continue Reading

References

Aug 1, 1992·The Australian & New Zealand Journal of Obstetrics & Gynaecology·S K TayE Au
Jan 1, 1990·Cancer Chemotherapy and Pharmacology·H KühnleW Achterrath
Mar 1, 1989·Journal of the National Cancer Institute·E J BuxtonD M Luesley
Dec 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F B StehmanR J Barrett
Jan 1, 1986·Cancer Chemotherapy and Pharmacology·R E ColemanC W Trask
Jan 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A M MuradJ C Ribalta
Jun 1, 1993·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T A FiltenborgM Rørth
Mar 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W P McGuireG Photopulos
Jan 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G A OmuraB Anderson
Apr 15, 1999·The New England Journal of Medicine·P G RoseS Insalaco

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Citations

Aug 6, 2013·Cancer Chemotherapy and Pharmacology·Taejong SongDuk Soo Bae
Oct 26, 2012·International Journal of Clinical Oncology·Tatsuru OharaNao Suzuki
Oct 14, 2005·Current Oncology Reports·Krishnansu S Tewari, Bradley J Monk
Feb 10, 2004·Gynecologic Oncology·Franco M MuggiaUNKNOWN Gynecologic Oncology Group study
Aug 21, 2003·Gynecologic Oncology·David G Mutch, Jeffrey D Bloss
Dec 24, 2003·The Cancer Journal·Tate Thigpen
Aug 9, 2006·Current Opinion in Oncology·David H Moore
Feb 1, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H O SmithD S Alberts
Jun 29, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·K SerkiesR Dziadziuszko
Jun 2, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H W HirteA M Oza
Nov 14, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S AckermannT Bogenrieder
Mar 9, 2010·Drugs·Alfonso Dueñas-GonzálezDéborah Martínez-Baños
Feb 21, 2014·The New England Journal of Medicine·Krishnansu S TewariBradley J Monk
Jan 17, 2014·Current Treatment Options in Oncology·Angel ChaoChyong-Huey Lai
Jul 27, 2007·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A PovedaA González Martín
Jun 26, 2012·Cancer Treatment Reviews·Giannis MountziosChristos A Papadimitriou
Aug 7, 2013·Taiwanese Journal of Obstetrics & Gynecology·Toshiharu Kamura, Kimio Ushijima
Sep 3, 2010·Critical Reviews in Oncology/hematology·Susan Davidson
Jul 28, 2015·American Journal of Obstetrics and Gynecology·Krista S Pfaendler, Krishnansu S Tewari
Jul 29, 2008·Cancer Treatment Reviews·D PectasidesE Pectasides
Jul 1, 2008·Gynecologic Oncology·Robert L Coleman, UNKNOWN Gynecologic Oncology Group's
Sep 7, 2007·Gynecologic Oncology·Isabelle CadronIgnace Vergote
Jan 9, 2007·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Dah-Ching DingYung-Hsiang Hsu
May 14, 2005·Critical Reviews in Oncology/hematology·Krystyna Serkies, Jacek Jassem
Jan 17, 2015·Clinical Therapeutics·Ramez N Eskander, Krishnansu S Tewari
Jan 30, 2007·Expert Opinion on Pharmacotherapy·Leslie M Randall-Whitis, Bradley J Monk
Apr 4, 2014·The Tohoku Journal of Experimental Medicine·Hyun-Joo SeolJong-Min Lee
Jan 3, 2013·Gynecologic Oncology·Charles A Leath, J Michael Straughn
May 15, 2010·Taiwanese Journal of Obstetrics & Gynecology·Yung-Liang LiuMu-Hsien Yu
Jul 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Harry J Long
Jul 30, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David Scott MillerRobert S Mannel
Oct 22, 2008·Seminars in Oncology·George A Omura, UNKNOWN Gynecologic Oncology Group
Mar 15, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Partha BasuRobert Petit
Nov 5, 2014·Therapeutic Advances in Medical Oncology·Ramez N Eskander, Krishnansu S Tewari
Jul 22, 2014·Journal of Gynecologic Oncology·Ramez N Eskander, Krishnansu S Tewari
Apr 7, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Irene RuengkhachornSaowalak Hunnangkul
Apr 28, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Virginia M RosenAijing Shang

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