Randomized trial of combination cytokine and adult autologous bone marrow progenitor cell administration in patients with non-ischaemic dilated cardiomyopathy: the REGENERATE-DCM clinical trial

European Heart Journal
Stephen HamshereAnthony Mathur

Abstract

The REGENERATE-DCM trial is the first phase II randomized, placebo-controlled trial aiming to assess if granulocyte colony-stimulating factor (G-CSF) administration with or without adjunctive intracoronary (IC) delivery of autologous bone marrow-derived cells (BMCs) improves global left ventricular (LV) function in patients with dilated cardiomyopathy (DCM) and significant cardiac dysfunction. Sixty patients with DCM and left ventricular ejection fraction (LVEF) at referral of ≤45%, New York Heart Association (NYHA) classification ≥2 and no secondary cause for the cardiomyopathy were randomized equally into four groups: peripheral placebo (saline), peripheral G-CSF, peripheral G-CSF and IC serum, and peripheral G-CSF and IC BMC. All patients, except the peripheral placebo group, received 5 days of G-CSF. In the IC groups, this was followed by bone marrow harvest and IC infusion of cells or serum on Day 6. The primary endpoint was LVEF change from baseline to 3 months, determined by advanced cardiac imaging. At 3 months, peripheral G-CSF combined with IC BMC therapy was associated with a 5.37% point increase in LVEF (38.30% ± 12.97 from 32.93% ± 16.46 P = 0.0138), which was maintained to 1 year. This was associated with a decrea...Continue Reading

References

Mar 1, 1981·The American Journal of Cardiology·V FusterR L Frye
Dec 8, 1994·The New England Journal of Medicine·G W Dec, V Fuster
Nov 1, 2005·Journal of the American College of Cardiology·Jonathan M HillRichard O Cannon
May 30, 2007·Archives of Internal Medicine·Ahmed Abdel-LatifBuddhadeb Dawn
Jul 9, 2008·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Christopher M KramerUNKNOWN Society for Cardiovascular Magnetic Resonance Board of Trustees Task Force on Standardized Protocols
Sep 29, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Marshall I HertzDavid O Taylor
Mar 2, 2010·Lancet·John Lynn Jefferies, Jeffrey A Towbin
Apr 10, 2010·Journal of the American College of Cardiology·Sandeep SethUNKNOWN AIIMS Stem Cell Study Group
Feb 18, 2012·The Cochrane Database of Systematic Reviews·David M CliffordEnca Martin-Rendon
Jul 10, 2013·Journal of Cardiac Failure·Johannes M I H GhoSteven A J Chamuleau
Jan 30, 2015·Circulation Research·Sheila A FisherEnca Martin-Rendon

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Citations

Nov 22, 2015·European Heart Journal·Thomas F Lüscher
Oct 1, 2015·European Heart Journal·Jens Kastrup
Jun 11, 2016·European Heart Journal·Thomas F Lüscher
Jun 19, 2016·European Heart Journal·Thomas F Lüscher
Jun 25, 2016·Journal of the American College of Cardiology·Alan G JappSanjay K Prasad
Jul 28, 2016·Journal of Cardiovascular Translational Research·Evelien NolletEmeline M Van Craenenbroeck
Feb 15, 2017·Analytical Cellular Pathology (Amsterdam)·Ming HaoWen Wang
Jan 24, 2018·European Journal of Clinical Investigation·Yanting WenQian Gao
Oct 19, 2017·Clinical Pharmacology and Therapeutics·Thomas J Povsic
Nov 1, 2018·Current Cardiology Reviews·Atena PourtajiAmir Hooshang Mohammadpour
May 22, 2019·Stem Cell Research & Therapy·Chao WangYongjian Li
Jul 7, 2019·Gene Therapy·Roberto Tofani Sant'AnnaRenato Abdala Karam Kalil
Aug 18, 2018·Journal of Biomedical Science·Jianquan ZhaoLongke Ran
Oct 20, 2017·European Heart Journal·Thomas F Lüscher
Jun 12, 2017·Heart Failure Reviews·V KatsiD Tousoulis
Jan 6, 2018·Npj Regenerative Medicine·Elena CambriaMaximilian Y Emmert
Mar 15, 2018·Stem Cells International·Gregor PoglajenPeter Černelč
Aug 23, 2019·Journal of the American Heart Association·Job A J VerdonschotStephane R B Heymans
Aug 13, 2020·Current Heart Failure Reports·Gregor PoglajenBojan Vrtovec
Jun 15, 2019·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Nandini Nair, Enrique Gongora
Apr 20, 2021·Cardiovascular Research·Roberto BolliArunpreet Kahlon
Jul 22, 2021·The Cochrane Database of Systematic Reviews·Rienzi Diaz-NavarroEva Madrid

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Methods Mentioned

BETA
dissection

Clinical Trials Mentioned

NCT01302171

Software Mentioned

GraphPad
SPSS
DCM
REGENERATE
Graphpad Prism

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