Randomized trial of endoscopic injection sclerosis with ethanolamine oleate and ethanol for bleeding peptic ulcer

Scandinavian Journal of Gastroenterology
J T MäkeläS T Laitinen

Abstract

Few studies have been done comparing ethanolamine oleate injection therapy with other sclerosing agents. Between September 1992 and August 1995, 78 consecutive patients presenting with a high-risk bleeding ulcer were randomized in a trial comparing endoscopic injection sclerotherapies with ethanolamine oleate and absolute ethanol. The groups were well matched in terms of sex, age, clinical features, endoscopic findings, and non-steroidal anti-inflammatory drug usage. We recorded in a prospective randomized trial the initial success of endoscopy, the rebleeding rate, permanent hemostasis, treatment failures, the need for surgery, mortality, and factors related to mortality. Initial hemostasis was achieved in 90% (38 of 42) of the ethanolamine oleate group and in 97% (35 of 36) of the ethanol group, and permanent hemostasis in 88% (37 of 42) and 92% (33 of 36), respectively. The rebleeding rate, 7% and 8%; the emergency surgery rate, 10% and 6%; the transfusion requirement, 4.8 +/- 3.3 units and 4.0 +/- 3.0 units; and the 30-day mortality, 12% and 3%, did not differ significantly between the ethanolamine oleate and ethanol groups. Mortality was significantly related to shock at admission, duodenal site of the ulcer, ulcer size gr...Continue Reading

References

Aug 17, 1974·Lancet·J A ForrestD J Shearman
Nov 1, 1982·Endoscopy·D Wördehoff, H Gros

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Citations

Feb 4, 2011·Pediatric Surgery International·Shafiqul Hoque, Bijoy Krishna Das
Oct 9, 2004·Gastrointestinal Endoscopy·Douglas G AdlerUNKNOWN ASGE
Jul 24, 2007·Gastrointestinal Endoscopy·Walter G ParkGeorge Triadafilopoulos
Jun 27, 2007·Gastrointestinal Endoscopy·Joseph CroffieBret T Petersen
Aug 23, 2000·Baillière's Best Practice & Research. Clinical Gastroenterology·N I Church, K R Palmer
Jan 16, 2003·The American Journal of Gastroenterology·Brennan M R SpiegelNimish B Vakil

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