Randomized trial of intraoperative mitomycin C in surgery for pterygium

American Journal of Ophthalmology
A PandaA Kumar

Abstract

To report the efficacy and safety of intraoperative application of mitomycin C in surgery for pterygium. In a prospective randomized and double-blind study done within a span of 2.5 years in 50 eyes (50 patients) with primary progressive pterygium, mitomycin C in a concentration of 0.02 mg/ml soaked in a sterile 5 x 5-mm sponge was applied over the bare sclera intraoperatively as an adjuvant therapy in 25 eyes after pterygium excision. These cases were compared with another 25 similar eyes that underwent the same procedure but in which gentamicin solution 0.3% was used instead of mitomycin C solution. Three eyes (12%) in the mitomycin C group showed recurrence within 7 months of surgery compared with eight eyes (32%) of the gentamicin control group within 3 to 5 months. Mild side effects, such as pain, photophobia, and delayed wound healing, were observed within the first 1 to 2 weeks postoperative in both groups. In the mitomycin C-treated group, corneal changes in the form of superficial punctate keratitis (three eyes) and limbal avascularity (two eyes) subsided within 2 weeks postoperatively. Follow-up time for these cases ranged from 18 to 21 months. A diluted solution of mitomycin C, 0.02 mg/ml, with an accurate size of st...Continue Reading

References

Jul 1, 1992·Ophthalmology·F D MackenzieA Green
Jul 1, 1988·Survey of Ophthalmology·P A Jaros, V P DeLuise
Dec 15, 1988·American Journal of Ophthalmology·S HayasakaT Setogawa
Jun 1, 1988·Ophthalmology·G SinghC S Foster
Nov 1, 1985·Ophthalmology·K R KenyonM E Hettinger
Feb 1, 1972·The British Journal of Ophthalmology·R M Youngson
Jun 1, 1967·American Journal of Ophthalmology·H Zauberman
Jul 1, 1980·The British Journal of Ophthalmology·K H Tarr, I J Constable
May 1, 1995·The British Journal of Ophthalmology·J Cano-ParraJ L Menezo
Aug 1, 1995·American Journal of Ophthalmology·P P ChenP J McDonnell
Mar 1, 1995·The British Journal of Ophthalmology·R RachmielS Levartovsky
Apr 1, 1994·Ophthalmology·J Frucht-Pery, M Ilsar
Jul 1, 1993·The British Journal of Ophthalmology·P S Mahar, G E Nwokora
Apr 1, 1996·The British Journal of Ophthalmology·L MastropasquaP Enrico Gallenga
Feb 1, 1948·The British Journal of Ophthalmology·A D'Ombrain
Dec 14, 2011·Epidemiology and Infection·I H M FriesemaUNKNOWN GEops Working Group

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Citations

Jul 25, 2012·Indian Journal of Ophthalmology·Khaled S Zaky, Yasser M Khalifa
Dec 17, 2009·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Iraklis VastardisDaniel M Aebersold
Jun 6, 2000·The British Journal of Ophthalmology·S AmanoK Eguchi
Apr 11, 2003·Survey of Ophthalmology·Lawrence W Hirst
Jul 18, 2008·International Journal of Radiation Oncology, Biology, Physics·Gustavo Arruda VianiEllen Carrara Fonseca
May 5, 2006·Clinical & Experimental Ophthalmology·Lawrence W Hirst
Aug 11, 2015·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Sophie BoucherKashif Baig
Oct 5, 2010·International Journal of Radiation Oncology, Biology, Physics·Takayuki YamadaMatsuyoshi Oinaka
Oct 25, 2003·Cornea·Rahamim Avisar, Dov Weinberger
Nov 18, 2017·The British Journal of Ophthalmology·Ellen Carrara FonsecaGustavo Viani Arruda
Jun 4, 2008·Cornea·Rahamim AvisarDov Weinberger
Sep 12, 2008·Korean Journal of Ophthalmology : KJO·Hyun Ho KimJae Pil Shin
Nov 4, 2017·BMC Ophthalmology·Myeong Yeon YiKyung Seek Choi
Jan 6, 2000·Current Opinion in Ophthalmology·M T CoroneoD Wakefield
Feb 27, 2015·Cornea·T Peter Lindquist, W Barry Lee
Sep 23, 2009·Cornea·Consuelo Pérez-RicoMiguel Angel Teus

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