Randomized trial of low-dose chemotherapy added to tamoxifen in patients with receptor-positive and lymph node-positive breast cancer

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Raimund JakeszGünther Steger

Abstract

To evaluate the outcome in patients with stage II hormone receptor-positive breast cancer treated or not treated with low-dose, short-term chemotherapy in addition to tamoxifen in terms of disease-free and overall survival. A total of 613 patients were randomized to receive either low-dose chemotherapy (doxorubicin 20 mg/m(2) and vincristine 1 mg/m(2) on day 1; cyclophosphamide 300 mg/m(2); methotrexate 25 mg/m(2); and fluorouracil 600 mg/m(2) on days 29 and 36 intravenously) or no chemotherapy in addition to 20 mg of tamoxifen orally for 2 years. A third group without any treatment (postmenopausal patients only) was terminated after the accrual of 79 patients due to ethical reasons. After a median follow-up period of 7.5 years, the addition of chemotherapy did not improve the outcome in patients as compared with those treated with tamoxifen alone, neither with respect to disease-free nor overall survival. Multivariate analysis of prognostic factors for disease-free survival revealed menopausal status, in addition to nodal status, progesterone receptor, and histologic grade as significant. Both untreated postmenopausal and tamoxifen-treated premenopausal patients showed identical prognoses significantly inferior to the tamoxife...Continue Reading

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Citations

Mar 18, 2003·International Journal of Cancer. Journal International Du Cancer·Sebastian F SchoppmannPeter Birner
Nov 17, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter H AhnBruce G Haffty
Mar 24, 2006·Breast Cancer Research and Treatment·Carlos Martínez-CampaSofía Ramos
Nov 21, 2000·Current Opinion in Oncology·A C Wolff
Mar 24, 2006·Breast Cancer Research and Treatment·Sebastian F SchoppmannPeter Birner
Feb 22, 2012·Breast Cancer Research and Treatment·Sebastian F SchoppmannPeter Birner
Jul 27, 2004·Annals of Surgery·Sebastian F SchoppmannUNKNOWN Austrian Breast and Colorectal Cancer Study Group
Apr 5, 2003·Annals of Surgery·Raimund JakeszUNKNOWN Austrian Breast & Colorectal Cancer Study Group
Nov 27, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S F SchoppmannP Birner

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