Randomized trial of oral versus sublingual misoprostol 24 h after mifepristone for medical abortion

Archives of Gynecology and Obstetrics
Krishna DahiyaSmiti Nanda

Abstract

To assess the efficacy, side effects, and acceptability of medical abortion using oral mifepristone (200 mg) followed 24 h later by oral or sublingual misoprostol (400 μg). A total of 93 women with pregnancies up to 56 days of gestational age were assigned to two groups according to the different misoprostol regimen (group I 400 μg orally and group II 400 μg sublingually). The principle outcome measure was complete abortion defined as a complete expulsion of intrauterine contents without a need for surgical intervention 7 days after the procedure. Successful abortion occurred in 87.5% of patients in group 1 and 95.5% patients in group 2 (p = 0.166, 95% CI -0.194, 0.033). The patient acceptability and satisfaction rates were similar in both the groups. It is concluded that 400 μg of sublingual misoprostol is as effective as oral misoprostol 24 h after mifepristone for medical abortion of ≤ 56 days.

References

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Citations

Nov 12, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yayi SunZhiying Hu
Feb 8, 2013·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Sheila RaghavanBeverly Winikoff
Sep 3, 2014·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Christian FialaKristina Gemzell-Danielsson
Mar 8, 2013·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Sheila RaghavanBeverly Winikoff
Aug 18, 2012·Contraception·Elizabeth G RaymondBeverly Winikoff
Jul 22, 2014·Journal of Forensic Sciences·Francesca CittadiniRiccardo Rossi

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