PMID: 8983611Sep 1, 1996Paper

Randomized trial of periportal peritoneal bupivacaine for pain relief after laparoscopic cholecystectomy

The British Journal of Surgery
D J AlexanderP M Goh

Abstract

The aim of this study was to determine whether injection of a long-acting local anaesthetic, in relation to the port sites at the level of the parietal peritoneum, would reduce postoperative pain following laparoscopic cholecystectomy. Patients were entered into a randomized, prospective, double-blind study comparing the effects of a standard technique, in which bupivacaine (total of 20 ml, 0.5 per cent) was injected into the subcutaneous periportal tissue around the four port sites, and a technique in which bupivacaine (total of 20 ml, 0.25 per cent) was injected into the subcutaneous periportal tissue as above with the addition of periportal parietal peritoneal injection of bupivacaine (total of 20 ml, 0.25 per cent). Two scores for pain, with the patient at rest, and on movement, were assessed 6 and 18 h after surgery using a visual analogue pain scale. Median pain score was significantly higher in patients who received standard technique (n = 40) than in those given peritoneal injection (n = 40) at both 6 (rest = 3.0 versus 1.0, movement = 5.0 versus 2.9) and 18 h (rest = 1.9 versus 0, movement = 3.2 versus 1.2). Both opiate and oral analgesic requirements were reduced in patients administered peritoneal injection, although...Continue Reading

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Citations

Oct 30, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S ColbertN Flynn
Jul 11, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·I O LeeS H Lim
Jun 3, 1999·The Surgical Clinics of North America·P W Peng, V W Chan
Jun 3, 1999·The Surgical Clinics of North America·D Tong, F Chung
Jun 8, 2013·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Keith J RobertsSaboor Khan
Mar 16, 2000·The British Journal of Surgery·V L Wills, D R Hunt
May 20, 2009·World Journal of Gastroenterology : WJG·Yu-Yin LiuYi-Yin Jan
Feb 1, 2002·The Journal of the American Association of Gynecologic Laparoscopists·Simon J GordonRichard Hiscock
Oct 1, 2004·World Journal of Surgery·Aydin InanCenap Dener
Jul 7, 2000·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·K I Gharaibeh, T M Al-Jaberi
Mar 13, 2014·The Cochrane Database of Systematic Reviews·Sofronis LoizidesBrian R Davidson

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