Randomized trial of radiotherapy plus concurrent-adjuvant chemotherapy vs radiotherapy alone for regionally advanced nasopharyngeal carcinoma

Journal of the National Cancer Institute
Anne W M LeeW H Lau

Abstract

Current practice of adding concurrent-adjuvant chemotherapy to radiotherapy (CRT) for treating advanced nasopharyngeal carcinoma is based on the Intergroup-0099 Study published in 1998. However, the outcome for the radiotherapy-alone (RT) group in that trial was substantially poorer than those in other trials, and there were no data on late toxicities. Verification of the long-term therapeutic index of this regimen is needed. Patients with nonkeratinizing nasopharyngeal carcinoma staged T1-4N2-3M0 were randomly assigned to RT (176 patients) or to CRT (172 patients) using cisplatin (100 mg/m(2)) every 3 weeks for three cycles in concurrence with radiotherapy, followed by cisplatin (80 mg/m(2)) plus fluorouracil (1000 mg per m(2) per day for 4 days) every 4 weeks for three cycles. Primary endpoints included overall failure-free rate (FFR) (the time to first failure at any site) and progression-free survival. Secondary endpoints included overall survival, locoregional FFR, distant FFR, and acute and late toxicity rates. All statistical tests were two-sided. The two treatment groups were well balanced in all patient characteristics, tumor factors, and radiotherapy parameters. Adding chemotherapy statistically significantly improved...Continue Reading

References

Jan 1, 1977·British Journal of Haematology·J Palek
Jan 1, 1981·Cancer·A B MillerA Winkler
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J D CoxT F Pajak
Apr 1, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·F B GearaL J Peters
Apr 29, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M Al-SarrafJ F Ensley
Feb 22, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S L WoldenD G Pfister
Mar 29, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Danny RischinLester Peters
Apr 17, 2002·International Journal of Radiation Oncology, Biology, Physics·Kwan-Hwa ChiKuang Y Chen
May 15, 2002·International Journal of Radiation Oncology, Biology, Physics·Nancy LeeKaren K Fu
Jul 27, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Edward ChowBernard Cummings
Feb 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jin-Ching LinWen-Yi Wang
Mar 22, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J L OhD J Haraf
Jul 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dora L W KwongDamon D K Choy
Jan 26, 2005·International Journal of Radiation Oncology, Biology, Physics·Skye Hongiun ChengAndrew T Huang
May 14, 2005·International Journal of Radiation Oncology, Biology, Physics·Abdullah Al-AmroMedhat El-Sebaie
Sep 20, 2005·International Journal of Radiation Oncology, Biology, Physics·Anne W M LeeW M Sze
Sep 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anne W M LeeUNKNOWN Hong Kong Nasopharyngeal Cancer Study Group
Oct 4, 2005·International Journal of Radiation Oncology, Biology, Physics·Faye M JohnsonBonnie S Glisson
Oct 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Li ZhangShao-Xiong Wu
Dec 27, 2005·International Journal of Radiation Oncology, Biology, Physics·Bertrand BaujatUNKNOWN MAC-NPC Collaborative Group
Jan 1, 2008·International Journal of Radiation Oncology, Biology, Physics·Wendy HaraQuynh-Thu Le
Mar 11, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Anne W M LeeTsz Kok Yau
Dec 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edwin P HuiAnthony T Chan

❮ Previous
Next ❯

Citations

Feb 15, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M R PosnerK J Cullen
May 11, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·X WuL Zhang
Feb 19, 2011·Current Opinion in Oncology·Sylvie RotteySimon Van Belle
Feb 14, 2013·Drug Design, Development and Therapy·Lu ZhangHai-Qiang Mai
Feb 8, 2014·Journal of Gastrointestinal Cancer·Jacopo Giuliani, Marina Marzola
Jun 28, 2011·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Xiayun HeTaifu Liu
Aug 1, 2012·Journal of Cancer Research and Clinical Oncology·Bin ZhangXue-Ping Feng
Oct 30, 2015·Expert Opinion on Pharmacotherapy·Tobenna Nwizu, David Adelstein
Jul 8, 2014·Expert Review of Anticancer Therapy·Tobenna Nwizu, David J Adelstein
Sep 18, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·An-Mei ZhangBo Zhu
Mar 20, 2012·Oral Oncology·Anne W M LeeL K Chan
Nov 30, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Anne W M LeeW H Lau
Oct 26, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Anne W M LeeWai-Hon Lau
Sep 1, 2015·Lancet·Melvin L K ChuaAnthony T C Chan
Mar 15, 2016·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Sung Ho MoonJong Hoon Lee
May 23, 2012·International Journal of Cancer. Journal International Du Cancer·Mo-Fa GuJian-Jun Li
Aug 6, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Yu-Pei ChenJun Ma
Nov 5, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Paolo Boscolo-RizzoMaria Cristina Da Mosto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.