Randomized trial of vonoprazan-based versus proton-pump inhibitor-based third-line triple therapy with sitafloxacin for Helicobacter pylori

Journal of Gastroenterology and Hepatology
Soichiro SueShin Maeda

Abstract

This was a prospective, randomized trial of the efficacy of vonoprazan-based and proton-pump inhibitor-based 7-day triple regimens with amoxicillin and sitafloxacin as a third-line therapy for eradicating Helicobacter pylori after failure of clarithromycin-based and metronidazole-based first-line and second-line therapy. We enrolled 63 patients positive for H. pylori in whom first-line and second-line regimens for eradicating failed. Patients were randomized to the V-AS group (vonoprazan 20-mg bid, amoxicillin 750-mg bid, and sitafloxacin 100-mg bid for 7 days) or PPI-AS group (esomeprazole 20-mg bid, rabeprazole 10-mg bid, or lansoprazole 30-mg bid; amoxicillin 750-mg bid; and sitafloxacin 100-mg bid for 7 days). We assessed the outcome of eradication therapy using the 13 C-urea breath test. We evaluated safety using patient questionnaires. This study was registered in the UMIN Clinical Trials Registry (UMIN000016336). The intention-to-treat and per-protocol eradication rates of V-AS were 75.8% (95% confidence interval [CI]: 57.7-88.9%) and 83.3% (95% CI: 65.3-94.4%), respectively. The respective eradication rates of PPI-AS were 53.3% (95% CI: 34.3-71.7%) and 57.1% (95% CI: 37.2-75.5%). In per-protocol analyses, the eradicatio...Continue Reading

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Citations

Mar 29, 2019·Journal of Gastroenterology and Hepatology·Sunny H Wong, Joseph Jy Sung
Jun 28, 2019·Internal Medicine·Shu KiyotokiIsao Sakaida
Aug 23, 2019·Current Opinion in Gastroenterology·Erick A Argueta, Steven F Moss
Jan 14, 2020·Chinese Medical Journal·Yi HuNong-Hua Lu
Jan 28, 2020·Journal of Gastroenterology and Hepatology·Jyh-Ming LiouMing-Shiang Wu
Jul 29, 2020·Antibiotics·Su Young Kim, Jun-Won Chung
Mar 21, 2019·The New England Journal of Medicine·Sheila E Crowe
May 1, 2020·World Journal of Gastroenterology : WJG·Hideki Mori, Hidekazu Suzuki
Jan 31, 2019·Frontiers in Pharmacology·Mitsushige Sugimoto, Yoshio Yamaoka
Oct 2, 2020·Pharmaceuticals·Muhammad MiftahussururYoshio Yamaoka
Apr 27, 2019·Frontiers in Pharmacology·Amin Talebi Bezmin Abadi, Enzo Ierardi
Sep 6, 2019·Helicobacter·Anthony O'ConnorColm O'Morain
Nov 3, 2020·Expert Opinion on Pharmacotherapy·Sotirios Georgopoulos, Vasilios Papastergiou
Feb 9, 2021·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Soichiro SueShin Maeda
Sep 13, 2020·Helicobacter·Anthony O'ConnorColm O'Morain
Jul 3, 2021·Journal of Clinical Medicine·Toshihiro NishizawaHidekazu Suzuki
Jul 13, 2021·International Journal of Immunopathology and Pharmacology·Wenwen GaoLu Wang
Nov 13, 2021·Biomaterials Science·Shreyasi MajumdarSairam Krishnamurthy
Mar 31, 2021·Gut and Liver·Jyh-Ming LiouUNKNOWN Taiwan Gastrointestinal Disease and Helicobacter Consortium

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