Randomly ordered addressable high-density optical sensor arrays

Analytical Chemistry
K L MichaelD R Walt

Abstract

Array-based sensors provide an architecture for multianalyte sensing. In this paper, we report a new approach for array fabrication. Sensors are made by immobilizing different reactive chemistries on the surfaces of microspheres. Sensor arrays are prepared by randomly distributing a mixture of microsphere sensors on an optical substrate containing thousands of micrometer-scale wells. The sensors occupy a different location from array to array; thus the identity of each sensor is ascertained and registered on the detector using encoding schemes, rather than by a predetermined location in the array. The approach thereby shifts the demand from fabrication to signal processing. The availability of commercial image analysis software makes such a shift both cost-effective and time efficient.

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Citations

Feb 8, 2000·Analytical Biochemistry·L C Taylor, D R Walt
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Mar 26, 2014·The Analyst·Anna KisielAgata Michalska

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