PMID: 16523666Mar 10, 2006Paper

Range of potential functions of the Drosophila melanogaster hdc gene

Genetika
A M GusachenkoL V Omel'ianchuk

Abstract

The Drosophila melanogaster hdc gene controls trachea branching, which starts during embryo development. Expression in imaginal disks and reproductive organs suggests additional functions for the hdc gene. The gene was demonstrated to have a maternal effect, which was denied previously. Analysis of cell proliferation in imaginal disks with hdc mutations showed that the gene does not possess tumor suppressor properties at the levels of mosaic cuticle clones of adults and transplanted imaginal disks. Transplanted imaginal disks homozygous, but not heterozygous, for an hdc mutation were found to affect oogenesis in the recipient females, implicating the hdc activity in exchanging signals between different organs. Amino acid sequence analysis of the Hdc protein revealed a region homologous to the human HRS proteins, which directly interact with the NF2 tumor suppressor on experimental evidence.

References

Apr 1, 1989·Genes & Development·M Gatti, B S Baker
Feb 23, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E Zelzer, B Z Shilo
Jan 10, 2003·Nucleic Acids Research·UNKNOWN FlyBase Consortium

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