Range uncertainties in proton therapy and the role of Monte Carlo simulations.

Physics in Medicine and Biology
Harald Paganetti

Abstract

The main advantages of proton therapy are the reduced total energy deposited in the patient as compared to photon techniques and the finite range of the proton beam. The latter adds an additional degree of freedom to treatment planning. The range in tissue is associated with considerable uncertainties caused by imaging, patient setup, beam delivery and dose calculation. Reducing the uncertainties would allow a reduction of the treatment volume and thus allow a better utilization of the advantages of protons. This paper summarizes the role of Monte Carlo simulations when aiming at a reduction of range uncertainties in proton therapy. Differences in dose calculation when comparing Monte Carlo with analytical algorithms are analyzed as well as range uncertainties due to material constants and CT conversion. Range uncertainties due to biological effects and the role of Monte Carlo for in vivo range verification are discussed. Furthermore, the current range uncertainty recipes used at several proton therapy facilities are revisited. We conclude that a significant impact of Monte Carlo dose calculation can be expected in complex geometries where local range uncertainties due to multiple Coulomb scattering will reduce the accuracy of ...Continue Reading

Associated Clinical Trials

References

Jan 1, 1977·International Journal of Radiation Oncology, Biology, Physics·M Goitein
Jan 1, 1986·Physics in Medicine and Biology·M UrieG T Chen
May 1, 1984·Physics in Medicine and Biology·M UrieM Wagner
Jan 1, 1996·Physics in Medicine and Biology·U SchneiderA Lomax
Jan 1, 1996·Physics in Medicine and Biology·U OelfkeM S Atkins
Jul 15, 1996·International Journal of Radiation Oncology, Biology, Physics·P L Petti
Aug 7, 1999·Medical Physics·D W LitzenbergF D Becchetti
Dec 1, 2000·Physics in Medicine and Biology·K Parodi, W Enghardt
Mar 30, 2001·Physics in Medicine and Biology·P van LuijkJ M Schippers
May 23, 2002·International Journal of Radiation Oncology, Biology, Physics·Harald PaganettiHerman D Suit
Oct 12, 2002·Physics in Medicine and Biology·Hanitra Szymanowski, Uwe Oelfke
Nov 17, 2004·Medical Physics·H Jiang, H Paganetti
Mar 31, 2005·Physics in Medicine and Biology·A TourovskyE Pedroni
Oct 21, 2005·Physics in Medicine and Biology·Martin SoukupMarkus Alber
Jan 18, 2007·Physics in Medicine and Biology·Oliver Jäkel, Petra Reiss
May 3, 2007·Physics in Medicine and Biology·Jan UnkelbachThomas Bortfeld
May 16, 2007·Medical Physics·D PflugfelderU Oelfke
Jun 5, 2007·International Journal of Radiation Oncology, Biology, Physics·Katia ParodiThomas Bortfeld
Feb 12, 2008·Physics in Medicine and Biology·Peter KimstrandErik Traneus
Feb 26, 2008·Physics in Medicine and Biology·Hsiao-Ming Lu
Aug 15, 2008·Physics in Medicine and Biology·Harald PaganettiMartijn Engelsman
Nov 11, 2008·Physics in Medicine and Biology·Hsiao-Ming Lu
Mar 27, 2009·Physics in Medicine and Biology·A StankovskiyL Demarzi
Jun 25, 2009·Physics in Medicine and Biology·Harald Paganetti
Feb 26, 2010·Physics in Medicine and Biology·Alexei V Chvetsov, Sandra L Paige

❮ Previous
Next ❯

Citations

Jan 29, 2013·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·T TessonnierM Ciocca
Nov 21, 2012·Nature Reviews. Clinical Oncology·David A Jaffray
Jan 23, 2013·Physics in Medicine and Biology·Abigail BesemerBryan Bednarz
Dec 7, 2013·Theranostics·Xuping Zhu, Georges El Fakhri
Dec 11, 2013·Medical Physics·Rebecca GrünMichael Scholz
Mar 7, 2014·Medical Physics·David C HansenThomas Sangild Sørensen
Mar 8, 2013·Medical Physics·Simon RitJean Michel Létang
May 3, 2014·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·A C KraanV Rosso
Mar 13, 2014·International Journal of Radiation Oncology, Biology, Physics·Brian WineyStefan Both
Sep 12, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Frank LohrUmberto Ricardi
Nov 6, 2014·Medical Physics·David C HansenJoao Seco
Nov 20, 2014·Practical Radiation Oncology·Carol HahnMichael Steinberg
Jun 5, 2014·The British Journal of Radiology·H Paganetti
Sep 27, 2016·Nuclear Instruments & Methods in Physics Research. Section A, Accelerators, Spectrometers, Detectors and Associated Equipment·J T TaylorI Tsurin
Feb 17, 2015·Cancers·Francesco Tommasino, Marco Durante
Mar 12, 2013·Seminars in Radiation Oncology·Jacob Flanz, Thomas Bortfeld
Mar 12, 2013·Seminars in Radiation Oncology·Harald Paganetti, Peter van Luijk
Mar 12, 2013·Seminars in Radiation Oncology·Martijn EngelsmanLei Dong
Mar 12, 2013·Seminars in Radiation Oncology·Robert C MillerBleddyn Jones
Jan 18, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Christian RichterMichael Baumann
Dec 3, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Guillaume JanssensEdmond Sterpin
Mar 16, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Wouter van ElmptFrank Verhaegen
Oct 16, 2015·International Journal of Radiation Oncology, Biology, Physics·Indrin J ChettyJohn W Wong
May 6, 2016·Frontiers in Oncology·Fernando Hueso-GonzálezWolfgang Enghardt
Apr 17, 2016·International Journal of Radiation Oncology, Biology, Physics·Andrea L RussoAnnie W Chan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.