Ranid Herpesvirus 3 and Proliferative Dermatitis in Free-Ranging Wild Common Frogs (Rana Temporaria)

Veterinary Pathology
F C OriggiM H Stoffel

Abstract

Amphibian pathogens are of current interest as contributors to the global decline of amphibians. However, compared with chytrid fungi and ranaviruses, herpesviruses have received relatively little attention. Two ranid herpesviruses have been described: namely, Ranid herpesvirus 1 (RHV1) and Ranid herpesvirus 2 (RHV2). This article describes the discovery and partial characterization of a novel virus tentatively named Ranid herpesvirus 3 (RHV3), a candidate member of the genus Batrachovirus in the family Alloherpesviridae. RHV3 infection in wild common frogs (Rana temporaria) was associated with severe multifocal epidermal hyperplasia, dermal edema, a minor inflammatory response, and variable mucous gland degeneration. Intranuclear inclusions were numerous in the affected epidermis together with unique extracellular aggregates of herpesvirus-like particles. The RHV3-associated skin disease has features similar to those of a condition recognized in European frogs for the last 20 years and whose cause has remained elusive. The genome of RHV3 shares most of the features of the Alloherpesviruses. The characterization of this presumptive pathogen may be of value for amphibian conservation and for a better understanding of the biology...Continue Reading

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Citations

Aug 29, 2020·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Matthias Licheri, Francesco C Origgi
Aug 30, 2018·Diseases of Aquatic Organisms·L H V FranklinosB Lawson
Jun 7, 2019·Proceedings of the National Academy of Sciences of the United States of America·David C LambJohn J Stegeman
Apr 6, 2021·Veterinary Pathology·Francesco C OriggiMichael H Stoffel
Jun 4, 2021·Diseases of Aquatic Organisms·Tobias EisenbergBenjamin Lamp

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Datasets Mentioned

BETA
AKV40702.1
AKV40686.1
AKV40689.1
KX832224

Methods Mentioned

BETA
PCR
light microscopy

Software Mentioned

iTEM
BLAST
VELVET
Geneious
ORFfinder
ClustalW
Integrative Genomic Viewer
Basic Local Alignment Search Tool ( BLAST
BLASTX
Easyfig

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