PMID: 8611398Apr 1, 1996Paper

Ranitidine and cimetidine differ in their in vitro and in vivo effects on human colonic cancer growth

British Journal of Cancer
J A LawsonD L Morris

Abstract

Histamine has recently been shown to be a growth factor for some gastric and colorectal cancer cells. Previous studies have shown that cimetidine blocks in vitro and in vivo histamine-stimulated growth and cAMP release from the human colonic cancer cell line, C170. In this study, ranitidine, another H2 receptor antagonist, did not affect either basal or histamine-stimulated in vitro proliferation of C170, and failed to prevent cAMP release in vitro. Ranitidine did not inhibit in vivo growth of C170 at a dose of 1, 10, 25, 50 or 100 mg/kg, in contrast to 50 mg/kg/day cimetidine, which produced 39.3% inhibition of tumour volume (p<0.01) after 23 days' treatment. Ranitidine did not inhibit in vivo histamine-stimulated growth of C170 cells . LIM2412, another colonic cancer cell line, was significantly stimulated by both cimetidine and ranitidine in vivo. Ranitidine had no effect on in vitro cell proliferation.

Citations

Oct 18, 2003·The Journal of Biological Chemistry·Sander H DiksMaikel P Peppelenbosch
Apr 2, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wei PanXiubao Ren
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