Ranitidine and nizatidine stimulate antral smooth muscle contractility via excitatory cholinergic mechanisms

Digestive Diseases and Sciences
H P ParkmanJ P Ryan

Abstract

Histamine type 2 receptor antagonists (H2RAs) have been found to alter gastric motility. The aims of this study were to determine if H2RAs affect antral contractility in vitro and the mechanism of this effect. Guinea pig antral muscle strips were pinned in an organ bath after removing the mucosa, and circular muscle tension was measured using an isometric force transducer. Gastric myocytes were isolated from guinea pig stomach using collagenase digestion, and cell lengths were measured using an image analysis system. In muscle strips, ranitidine and nizatidine increased the amplitude of spontaneous phasic antral contractions in a concentration-dependent fashion with threshold concentrations of 5 microM. The order of potency for the H2RAs was ranitidine = nizatidine > cimetidine > famotidine. The contractile effects of ranitidine and nizatidine were reduced, but not abolished, by tetrodotoxin and omega-conotoxin GVIA and nearly abolished by atropine. In isolated cells, ranitidine and nizatidine, but not famotidine or cimetidine, induced concentration-dependent cell shortening, with maximal shortening at 10 microM. These contractile effects of ranitidine and nizatidine in isolated cells were inhibited by atropine. Ranitidine and ...Continue Reading

Citations

Feb 5, 2009·Expert Opinion on Pharmacotherapy·Savio C Reddymasu, Richard W McCallum
Nov 4, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Paul J SimpsonSimon Woods
Nov 20, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K IkeoH Miwa
Aug 9, 2007·Digestive Diseases and Sciences·Jari KoskenpatoMartti Färkkilä
Sep 21, 2006·Journal of Gastroenterology and Hepatology·Yoshiko TakahashiYoshikazu Kinoshita
Sep 4, 2008·American Journal of Veterinary Research·Omar MaherJack R Snyder
Jun 13, 2012·Current Gastroenterology Reports·Reza A HejaziIrene Sarosiek
Nov 6, 2014·European Journal of Clinical Investigation·Hiroaki ZaiHiroki Kato

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