PMID: 9432341Feb 12, 1998Paper

Ranitidine bismuth citrate with clarithromycin for the eradication of Helicobacter pylori and for ulcer healing

Helicobacter
R E PounderB Ohlin

Abstract

In a pilot study, ranitidine bismuth citrate (RBC; Pylorid, Tritec) in coprescription with clarithromycin achieved a Helicobacter pylori eradication rate (based on 13C urea breath test alone) of 83%. The aim of the current study was to validate this finding by using three diagnostic tests and a larger group of H. pylori-positive patients with active duodenal ulcer. In a blinded study, 95 patients were given either 4 weeks of treatment with RBC, 400 mg bid, alone (RBC400, n = 31) or RBC, 400 mg bid or 800 mg bid, in coprescription with clarithromycin, 250 mg qid for 14 days, followed by 14 days of RBC, 400 mg bid, alone (RBC400 + CLAR and RBC800 + CLAR, respectively; n = 32 for each). Rates of ulcer healing at week 4 and of H. pylori eradication (assessed by antral and corpus urease tests and histology and by 13C urea breath test) at week 8 were compared, together with the incidence of adverse events. All three regimens were effective at duodenal ulcer healing and were tolerated well. The coprescription regimens gave significantly higher observed H. pylori eradication rates (82% and 74% for RBC400 + CLAR and RBC800 + CLAR) compared with RBC400 (0%; p < .001). RBC in dual therapy with clarithromycin provides excellent H. pylori e...Continue Reading

References

May 1, 1991·Journal of Gastroenterology and Hepatology·A B Price
Jan 1, 1995·Scandinavian Journal of Gastroenterology. Supplement·J S Dixon
Aug 1, 1996·Alimentary Pharmacology & Therapeutics·L A TillmanJ R Wood
Feb 1, 1997·Alimentary Pharmacology & Therapeutics·A T AxonP D Rooprams

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Citations

Feb 1, 1997·Alimentary Pharmacology & Therapeutics·A T AxonP D Rooprams
Aug 28, 2004·The American Journal of Gastroenterology·Alexander C FordPaul Moayyedi
Apr 20, 2016·The Cochrane Database of Systematic Reviews·Alexander C FordPaul Moayyedi

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