Ranitidine Inhibition of Breast Tumor Growth Is B Cell Dependent and Associated With an Enhanced Antitumor Antibody Response

Frontiers in Immunology
Dakota RogersJean S Marshall

Abstract

The histamine receptor 2 antagonist ranitidine is a commonly used, non-prescription, medication. It limits the development, growth, and metastasis of breast cancers in mouse models of disease. In this study, we examined the role of B cells in this response, the impact of ranitidine on the development of antitumor antibodies and subpopulations of natural killer cells using murine breast cancer models. Peripheral blood granulocyte populations were assessed in both E0771-GFP and 4T1 orthotopic tumor-bearing mice by evaluation of stained blood smears. Antibody responses were assessed both in terms of the levels of anti-GFP antibodies detected by enzyme-linked immunosorbent assay and also by antibody binding to the surface of tumor cells evaluated by flow cytometry. B cell and NK cell populations were examined in the draining lymph nodes and spleens of tumor-bearing animals, by flow cytometry with and without ranitidine treatment. Oral ranitidine treatment was not associated with changes in peripheral blood granulocyte populations in tumor-bearing mice. However, ranitidine treatment was associated with the development of enhanced antitumor antibody responses. This was not limited to the tumor setting since ranitidine-treated mice im...Continue Reading

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Citations

Nov 11, 2018·British Journal of Pharmacology·Noelia A MassariVanina A Medina
Jun 7, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Bárbara CostaNuno Vale
May 2, 2021·Scientific Reports·Dihia MeghnemJean S Marshall
Oct 6, 2021·Pharmacology Research & Perspectives·María de la Paz SarasolaVanina A Medina

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Methods Mentioned

BETA
FACS
FCS
Enzyme-linked immunosorbent assay
ELISA
flow cytometry

Software Mentioned

FCS express
Prism

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