Ranitidine is unable to maintain gastric pH levels above 4 in septic patients

Journal of Critical Care
Cristina B Terzi CoelhoNelson Adami Andreollo

Abstract

The study aimed to evaluate whether ranitidine and pantoprazole are able to maintain gastric pH >or=4 in septic patients. Twenty intensive care unit patients from a university teaching hospital with sepsis were included in this study. Ten patients received ranitidine (50 mg as an intermittent bolus 3 times a day) and 10 received pantoprazole (40 mg as an intermittent bolus twice a day). Gastric pH was measured continuously for 48 hours. Endoscopy of the upper digestive tract, gastric biopsy, and investigation for Helicobacter pylori were carried out before and at the end of the study. pH values >or=4 were maintained for 46.27% +/- 38.21% and 81.57% +/- 19.65% of study time in the ranitidine and pantoprazole groups, respectively (P = .04). Intravenous ranitidine was unable to maintain gastric pH above 4 in septic patients. All cases in the ranitidine group in whom pH remained above 4 had gastric hypotrophy or atrophy. Pantoprazole successfully maintained pH levels above 4.

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Citations

Jan 1, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Claudia C M van den BraakThomas Ludwig
Mar 20, 2012·Digestive Diseases and Sciences·Iyad A IssaLama Soubra
Jun 5, 2018·The Cochrane Database of Systematic Reviews·Ingrid ToewsJoerg J Meerpohl

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