RANK ligand, RANK, and OPG expression in type II collagen-induced arthritis mouse

Histochemistry and Cell Biology
Hiroyuki MoriSohei Kitazawa

Abstract

Rheumatoid arthritis (RA) is a systemic disorder characterized by synovial inflammation and subsequent destruction and deformity of synovial joints. The articular lesions start with synovitis, focal erosion of unmineralized cartilage, and then culminate in the destruction of subarticular bone by pannus tissue. Periarticular osteopenia and systemic osteoporosis follow as late complications of RA. Osteoclasts, specialized cells that resorb bone, play a central role in developing these osteolytic lesions. To elucidate the mechanism of osteoclastogenesis and bone destruction in autoimmune arthritis, we investigated the expression of RANK ligand (RANKL), RANK, and osteoprotegerin (OPG) mRNA in a mouse type II collagen-induced arthritis (CIA) model by in situ hybridization. The results indicated that most of the TRAP-positive mono- and multinucleated cells in the inflamed and proliferating synovium and in the pannus were RANK-positive authentic osteoclasts and their precursors. In the inflamed synovium and pannus of the mouse CIA model, synovial fibroblastic cells around these RANK-positive cells were strongly positive for RANKL. Moreover, RANKL-positive osteoblasts on the endosteal bone surface, at a distance from the affected synov...Continue Reading

Citations

Dec 23, 2004·Histochemistry and Cell Biology·Esther Asan, Detlev Drenckhahn
Nov 12, 2005·Histochemistry and Cell Biology·Kenta KishimotoSohei Kitazawa
May 15, 2012·Endocrine·Kathrin SinningenLorenz C Hofbauer
Jul 23, 2013·BMC Complementary and Alternative Medicine·Chen Chao WeiChen Yong Qiang
Dec 17, 2008·Annals of the New York Academy of Sciences·Andreas Leibbrandt, Josef M Penninger
Sep 2, 2008·Journal of Cellular Biochemistry·Junko IshiiSohei Kitazawa
Nov 25, 2004·Cytokine & Growth Factor Reviews·Sandrine TheoleyreDominique Heymann
Sep 8, 2004·International Immunopharmacology·Hirohisa MorohashiKiyohiro Nishikawa
Aug 6, 2010·Molecular and Cellular Endocrinology·Ulrika IslanderHans Carlsten
Mar 24, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M C BezerraR M R Pereira
Jun 20, 2017·The FEBS Journal·Yizhou WangWim J Quax
Jan 23, 2018·Histochemistry and Cell Biology·Riko KitazawaSohei Kitazawa
Oct 4, 2005·Arthritis and Rheumatism·Elena NeumannUlf Müller-Ladner
Dec 17, 2002·Histochemistry and Cell Biology·Esther Asan
Apr 23, 2003·Current Opinion in Rheumatology·Tomoki NakashimaJosef M Penninger
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shiva ShahraraRichard M Pope
May 4, 2018·Histochemistry and Cell Biology·Sohei KitazawaRiko Kitazawa
May 2, 2020·Calcified Tissue International·Frideriki PoutoglidouDimitrios Kouvelas
Dec 1, 2012·Clinical Kidney Journal·Fabio Malberti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.