Rank Order Coding: a Retinal Information Decoding Strategy Revealed by Large-Scale Multielectrode Array Retinal Recordings

ENeuro
Geoffrey PortelliEvelyne Sernagor

Abstract

How a population of retinal ganglion cells (RGCs) encodes the visual scene remains an open question. Going beyond individual RGC coding strategies, results in salamander suggest that the relative latencies of a RGC pair encode spatial information. Thus, a population code based on this concerted spiking could be a powerful mechanism to transmit visual information rapidly and efficiently. Here, we tested this hypothesis in mouse by recording simultaneous light-evoked responses from hundreds of RGCs, at pan-retinal level, using a new generation of large-scale, high-density multielectrode array consisting of 4096 electrodes. Interestingly, we did not find any RGCs exhibiting a clear latency tuning to the stimuli, suggesting that in mouse, individual RGC pairs may not provide sufficient information. We show that a significant amount of information is encoded synergistically in the concerted spiking of large RGC populations. Thus, the RGC population response described with relative activities, or ranks, provides more relevant information than classical independent spike count- or latency- based codes. In particular, we report for the first time that when considering the relative activities across the whole population, the wave of fir...Continue Reading

Citations

Dec 23, 2016·Journal of Integrative Neuroscience·Charlotte HéricéAndré Garenne
May 7, 2019·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Davis M Aasen, M Natalia Vergara
Aug 24, 2017·Scientific Reports·Valentina PasqualeMichela Chiappalone
Jun 29, 2018·Interface Focus·Michael HopkinsSteve B Furber
Dec 25, 2018·Frontiers in Cellular Neuroscience·Jonathan JoutyMatthias H Hennig
Oct 24, 2019·Scientific Reports·Ádám Jonatán TengölicsBéla Völgyi
Nov 1, 2017·Advanced Biosystems·Günther ZeckRoland Thewes
Nov 23, 2018·Biosensors & Bioelectronics·Gian Nicola AngotziLuca Berdondini

Related Concepts

Nerve Impulses
Metazoa
Mice, Inbred C57BL
Microelectrodes
Photic Stimulation
Retinal Ganglion Cells
Signal Processing, Digital
Vision
Datasets as Topic
Evoked Potentials

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