Rankings and symptom assessments of side effects from chemotherapy: insights from experienced patients with ovarian cancer

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Charlotte C SunEdward B Rubenstein

Abstract

Although many patients with ovarian cancer achieve favorable responses to primary chemotherapy, the majority of women will experience recurrence of their cancer. Selection of second- or third-line chemotherapy ultimately depends on patient preferences for different side effects. To better understand this process, we evaluated preferences and symptom distress in patients with ovarian cancer. A total of 70 women with ovarian cancer who had previously received at least three cycles of platinum-based chemotherapy and currently undergoing chemotherapy for newly diagnosed or recurrent disease were interviewed in an outpatient chemotherapy clinic. The patients were asked to rank order 27 health states using a modified visual analog scale and to complete the Memorial Symptom Assessment Scale (MSAS). Most favorable health states included perfect health, clinical remission and complete control of chemotherapy-induced nausea and vomiting (CINV). Least favorable health states included more severe CINV health states and death. Patients on first-line chemotherapy had less symptom distress, and rated sexual dysfunction, fatigue and memory loss more favorably than patients on second- or third-line chemotherapy (P<0.05). Married patients genera...Continue Reading

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Feb 12, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Brendan JohnsonRobert Blum
Feb 3, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Andrea LiekwegUlrich Jaehde
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Feb 27, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Mary Lou AffrontiHenry S Friedman
Mar 22, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Shota HamadaKoji Kawakami
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