RANKL inhibitors induce osteonecrosis of the jaw in mice with periapical disease

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Tara L AghalooSotirios Tetradis

Abstract

Antiresorptive medications are essential in treating diseases of pathologic osteoclastic bone resorption, including bone cancer and osteoporosis. Bisphosphonates (BPs) are the most commonly used antiresorptives in clinical practice. Although inhibition of bone resorption is important in regulating unwanted malignant and metabolic osteolysis, BP treatment is associated with potential side effects, including osteonecrosis of the jaws (ONJ). Recently, non-BP antiresorptive medications targeting osteoclastic function and differentiation, such as denosumab, have entered the clinical arena. Denosumab treatment results in a similar rate of ONJ as BPs. Animal models of ONJ, using high-dose BP treatment in combination with tooth extraction or dental disease, provide valuable tools and insight in exploring ONJ pathophysiology. However, the ability of other antiresorptives to induce ONJ-like lesions in animal models has not been explored. Such studies would be beneficial in providing support for the role of osteoclast inhibition in ONJ pathogenesis versus a direct BP effect on oral tissues. Here, we tested the ability of the receptor activator of NF-κB ligand (RANKL) inhibitors RANK-Fc (composed of the extracellular domain of RANK fused t...Continue Reading

References

Oct 1, 1991·Journal of Dental Research·C Y Wang, P Stashenko
Oct 23, 1997·British Journal of Haematology·C M ShipmanP I Croucher
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·H YasudaT Suda
Jun 30, 2000·Journal of Bone and Mineral Metabolism·T TsurukaiT Suda
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·H SasakiP Stashenko
May 29, 2001·Current Pharmaceutical Design·P J Kostenuik, V Shalhoub
Jan 28, 2003·Cancer·Emilia Mia Sordillo, Roger Niles Pearse
Jun 28, 2003·Journal of Periodontal Research·Tania CrottiDavid Haynes
Sep 11, 2003·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Robert E Marx
Dec 3, 2003·Australian Dental Journal·C S Farah, N W Savage
May 4, 2004·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Salvatore L RuggieroStephen L Engroff
Jun 5, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Pirow J BekkerAlex M DePaoli
Oct 18, 2005·Cancer Treatment Reviews·Philippe Clézardin
Oct 26, 2005·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Robert E MarxVishtasb Broumand
Dec 20, 2005·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Shabnum MeerTerence Alexander
Jun 6, 2006·Cytokine & Growth Factor Reviews·Giorgio Zauli, Paola Secchiero
Oct 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anke J RoelofsMichael J Rogers
Mar 6, 2007·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Nobuyuki KawashimaHideaki Suda
Jun 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Robert E MillerWilliam C Dougall
Jul 5, 2007·Journal of Periodontology·Qiming JinWilliam V Giannobile
Aug 1, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sundeep KhoslaUNKNOWN American Society for Bone and Mineral Research
Nov 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marina StolinaPaul Kostenuik
Mar 14, 2008·Journal of Cellular Physiology·Estelle ChamouxSophie Roux
Apr 9, 2008·Archives of Biochemistry and Biophysics·Brendan F Boyce, Lianping Xing
Apr 25, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Michael S OminskyPaul J Kostenuik
Aug 19, 2008·European Journal of Cell Biology·Penny Reid, Ingunn Holen
Nov 18, 2008·Cellular and Molecular Life Sciences : CMLS·G ZauliP Secchiero
Nov 20, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Paul J KostenuikJohn K Sullivan
Mar 5, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Michael S OminskyPaul J Kostenuik
Apr 10, 2009·Journal - Canadian Dental Association = Journal De L'Association Dentaire Canadienne·Leandro ChambroneLuiz Armando Chambrone
Apr 25, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Salvatore L RuggieroUNKNOWN American Association of Oral and Maxillofacial Surgeons
Apr 25, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Matthew R Allen, David B Burr
Apr 29, 2009·The Keio Journal of Medicine·Steeve Kwan TatJohanne Martel-Pelletier
Jul 16, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Sun Wook ChoChan Soo Shin

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Citations

Sep 30, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Simon CheongSotirios Tetradis
Feb 10, 2016·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·Raphaela Capella de Souza PóvoaFábio Ramoa Pires
Mar 3, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Rafael Scaf de MolonSotirios Tetradis
Oct 23, 2015·Journal of Endodontics·Marcelo Tadahiro WayamaKazuo Sano
Aug 19, 2015·Oral and Maxillofacial Surgery Clinics of North America·Matthew R Allen
Nov 22, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Aliya A KhanUNKNOWN International Task Force on Osteonecrosis of the Jaw
Jan 7, 2015·Clinical Radiology·M HarmonS A O'Keeffe
May 13, 2014·La Presse médicale·Holger MoysichPoramate Pitak-Arnnop
Jul 31, 2016·Current Osteoporosis Reports·Jenny A F VermeerVincent Everts
Apr 3, 2018·Biological & Pharmaceutical Bulletin·Miku KuritaniMasamichi Takami
Jan 13, 2018·Journal of Cellular Physiology·Jorge W Vargas-FrancoFrédéric Lézot
Mar 3, 2018·Journal of Dental Research·C F FrancisconiG P Garlet
Aug 10, 2018·The Journal of International Medical Research·Henrik HoltmannRita Depprich
Sep 6, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Danny HadayaSotirios Tetradis
Aug 20, 2019·Journal of the National Cancer Institute. Monographs·Cesar A MiglioratiDouglas E Peterson
Mar 8, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Rafael Scaf de MolonSotirios Tetradis
Nov 6, 2017·Calcified Tissue International·Yves MaugarsChristelle Darrieutort-Laffite
Aug 30, 2018·Current Osteoporosis Reports·J ChangL K McCauley
Dec 31, 2016·Journal of Bone and Mineral Metabolism·UNKNOWN Japanese Allied Committee on Osteonecrosis of the JawSatoru Toyosawa
May 15, 2021·International Journal of Implant Dentistry·Mampei KawaharaTakashi Sawase
Sep 13, 2021·Journal of Periodontology·Koma SandaKiyoshi Koyano

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