RANKL, osteopontin, and osteoclast homeostasis in a hyperocclusion mouse model.

European Journal of Oral Sciences
Cameron WalkerThomas G H Diekwisch

Abstract

The biological mechanisms that maintain the position of teeth in their sockets establish a dynamic equilibrium between bone resorption and apposition. In order to reveal some of the dynamics involved in the tissue responses towards occlusal forces on periodontal ligament (PDL) and alveolar bone homeostasis, we developed the first mouse model of hyperocclusion. Swiss-Webster mice were kept in hyperocclusion for 0, 3, 6, and 9 d. Morphological and histological changes in the periodontium were assessed using micro-computed tomography (micro-CT) and ground sections with fluorescent detection of vital dye labels. Sections were stained for tartrate-resistant acid phosphatase, and the expression of receptor activator of nuclear factor-kappaB ligand (RANKL) and osteopontin (OPN) was analyzed by immunohistochemistry and real-time polymerase chain reaction (PCR). Traumatic occlusion resulted in enamel surface abrasion, inhibition of alveolar bone apposition, significant formation of osteoclasts at 3, 6 and 9 d, and upregulation of OPN and RANKL. Data from this study suggest that both OPN and RANKL contribute to the stimulation of bone resorption in the hyperocclusive state. In addition, we propose that the inhibition of alveolar bone app...Continue Reading

References

Jan 1, 1995·Cell and Tissue Research·T G DiekwischH C Slavkin
Aug 26, 1998·Biochemical and Biophysical Research Communications·R FaccioA J Pelletier
Jun 3, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K TeraiS Nomura
Jun 8, 2000·Matrix Biology : Journal of the International Society for Matrix Biology·S Nomura, T Takano-Yamamoto
Sep 1, 2000·Science·S L Teitelbaum
Oct 6, 2000·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·J SodekM D McKee
Jan 29, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hiroyuki KanzakiHideo Mitani
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Dec 7, 2002·Calcified Tissue International·M A Chellaiah, K A Hruska
May 16, 2003·Nature·William J BoyleDavid L Lacey
Feb 8, 2005·Biochemical and Biophysical Research Communications·Harry C BlairMone Zaidi
Dec 17, 2005·Trends in Molecular Medicine·Teiji WadaJosef M Penninger
Apr 22, 2006·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Vinod Krishnan, Ze'ev Davidovitch
Jun 7, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Shinji FujiharaKeiji Moriyama
Oct 4, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Xianghong LuanThomas G H Diekwisch

❮ Previous
Next ❯

Citations

Aug 25, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T-I ChiangY-W Cheng
Jan 28, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Tatiana Beber Teixeira-SalumAdriano Motta Loyola
Sep 14, 2010·Archives of Oral Biology·Tetsuomi NemotoKoji Okabe
Jan 27, 2015·Orthodontics & Craniofacial Research·G R S Naveh, S Weiner
Apr 17, 2010·International Journal of Dentistry·Teruyoshi KoshiharaTakashi Inoue
May 20, 2016·Journal of Oral and Maxillofacial Pathology : JOMFP·Atif A Ahmed, Charles Dunlap
Feb 3, 2012·Archives of Oral Biology·Hao-yuan WanZhen-zhen Shang
Nov 5, 2016·Journal of Dental Research·A Iglesias-Linares, J K Hartsfield
Apr 1, 2016·Journal of Dental Research·N ZhaoL F Bonewald
Jul 2, 2015·Journal of Dental Research·Y SoenjayaH A Goldberg
Mar 12, 2011·Journal of Dental Research·K T GotoK Okabe
Nov 13, 2012·Journal of Dental Research·T TsutsumiK Okabe
Mar 11, 2020·Journal of Periodontal Research·Yoichi AritaRyuji Sakagami
Dec 16, 2017·Journal of Prosthodontic Research·Takashi TsutsumiYutaka Takahashi
Apr 13, 2011·International Journal of Paediatric Dentistry·Mabel M R CordeiroClaudia P Figueiredo
Apr 24, 2020·Journal of Periodontal Research·Liyuan ChenYongmei Hua
Mar 21, 2019·Periodontology 2000·Euloir Passanezi, Adriana Campos Passanezi Sant'Ana
Jan 10, 2019·Calcified Tissue International·Danying ChenPenglai Wang
Apr 12, 2019·Journal of Dental Research·Q XuJ A Helms
Jun 26, 2020·Frontiers in Physiology·Beatriz Carmona FerreiraAna Cláudia Rossi
Aug 2, 2017·Journal of Dental Research·Y WengY Sun
Jun 4, 2021·Journal of Pain Research·Ting XiangDong-Yuan Cao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved