Ranolazine: focusing on angina pectoris

Drugs of Today
Peter A McCullough

Abstract

Chronic stable angina is common and is a difficult-to-manage problem when patients begin to fail conventional therapy especially when maximal revascularization has been provided. The most promising agent in development is ranolazine, a late sodium channel inhibitor and partial fatty oxidation inhibitor which has unique and desirable anti-ischemic and electrophysiologic properties. This agent is likely to become standard therapy for chronic stable angina and may play a future role in the management of acute coronary syndromes.

Citations

Jun 12, 2009·Journal of Medicinal Chemistry·Bruno Le GrandBernard Vacher

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