Ranolazine for Angina in Hypertrophic Cardiomyopathy

Case Reports in Cardiology
Akhtar Amin, Bernard Kim

Abstract

Ranolazine is an antianginal and works by inhibiting late-sodium current (INaL). However, its use is limited mostly to patients with coronary artery disease. However, literature has shown its potential benefit in relieving angina in hypertrophic cardiomyopathy. Hereby, we discuss two cases where ranolazine led to improvement in angina refractory to beta-blockers. In conclusion, ranolazine can be considered as a potential antianginal drug in patients with hypertrophic cardiomyopathy refractory to beta-blockers.

References

Jan 22, 2004·JAMA : the Journal of the American Medical Association·Bernard R ChaitmanUNKNOWN Combination Assessment of Ranolazine In Stable Angina (CARISA) Investigators
Aug 1, 2006·Journal of the American College of Cardiology·Peter H StoneUNKNOWN ERICA Investigators
Aug 10, 2012·Lancet·Barry J Maron, Martin S Maron
Jun 21, 2015·Trends in Cardiovascular Medicine·Jonathan C Makielski
Oct 16, 2016·Journal of the American College of Cardiology·James L GentryAndrew Wang

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