RANTES (CCL5) regulates airway responsiveness after repeated allergen challenge

American Journal of Respiratory Cell and Molecular Biology
Toshiyuki KoyaErwin W Gelfand

Abstract

RANTES (CC chemokine ligand 5) contributes to airway inflammation through accumulation of eosinophils, but the exact role of RANTES (CCL5) is not defined. C57BL/6 mice, sensitized by injection of ovalbumin (OVA) on Days 1 and 14, were challenged with OVA on Days 28, 29, and 30 (3 challenges, short-term-challenge model) or on Days 28, 29, 30, 36, 40, 44, and 48 (7 challenges, repeated-challenge model) and evaluated 48 h later. Anti-mouse RANTES was given intravenously, and recombinant mouse RANTES or PBS was given intratracheally. These reagents were given on Days 28, 29, and 30 in the short-term-challenge study and on Days 44 and 48 in the repeated-challenge study. After short-term challenge, there were no effects after administration of anti-RANTES or RANTES. In the repeated-challenge study, although control mice showed a decrease in airway hyperresponsiveness, administration of anti-RANTES sustained and enhanced airway hyperresponsiveness and increased goblet cell numbers. In contrast, administration of RANTES normalized airway function but reduced goblet cell numbers. IL-12 and IFN-gamma levels in BAL decreased in the anti-RANTES group and increased in the RANTES group. IFN-gamma-producing CD4 T cells in lung, and IFN-gamma ...Continue Reading

References

Aug 1, 1992·The Journal of Experimental Medicine·Y KameyoshiJ M Schröder
May 1, 1991·Cytokine·T J Schall
May 1, 1991·The Journal of Allergy and Clinical Immunology·A B Kay
Mar 1, 1987·The Journal of Experimental Medicine·J JongstraA M Krensky
Jul 1, 1995·American Journal of Respiratory Cell and Molecular Biology·N W LukacsS L Kunkel
Jan 1, 1995·The Journal of Allergy and Clinical Immunology·M BoguniewiczD Y Leung
Jan 1, 1994·Annual Review of Immunology·B S BochnerL M Lichtenstein
Jan 1, 1994·The European Respiratory Journal·H ChenY Kawakami
Jan 1, 1996·Journal of Leukocyte Biology·D D TaubW J Murphy
Apr 1, 1996·American Journal of Respiratory and Critical Care Medicine·R AlamN Ida
Nov 1, 1996·Journal of Leukocyte Biology·N W LukacsS L Kunkel
Dec 1, 1996·American Journal of Respiratory and Critical Care Medicine·N BerkmanK F Chung
Mar 1, 1997·American Journal of Respiratory Cell and Molecular Biology·E M HesselF P Nijkamp
Oct 6, 1997·The European Respiratory Journal·S G FolkardA B Millar
Feb 26, 1998·American Journal of Respiratory Cell and Molecular Biology·S MatsukuraM Adachi
Jul 7, 1998·The Journal of Experimental Medicine·J A GonzaloJ C Gutierrez-Ramos
Sep 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M BoguniewiczD Y Leung
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J W LillardJ R McGhee
Feb 24, 2001·Bratislavské lekárske listy·M Buc, M Bucova
Mar 17, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R S PeeblesA Togias
Apr 5, 2001·Trends in Immunology·V Appay, S L Rowland-Jones
Mar 22, 2002·Nature Reviews. Immunology·N W Lukacs
Apr 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Brigitte G DornerRichard A Kroczek
May 16, 2002·Molecular Immunology·S Romagnani
Jun 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Joel N KlineVipul V Jain
Jan 18, 2003·The Journal of Allergy and Clinical Immunology·Nives Zimmermann, Marc E Rothenberg
Jan 31, 2003·European Journal of Immunology·Kim K TekkanatNicholas W Lukacs
Feb 18, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yassine AmraniReynold A Panettieri
Jun 13, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T IshikawaK Shimokata
Feb 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nobuaki MiyaharaErwin W Gelfand
Aug 13, 2004·American Journal of Respiratory and Critical Care Medicine·Rakesh K KumarPaul S Foster
Jul 6, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Alan M Krensky, Carol Clayberger
Sep 30, 2005·American Journal of Respiratory and Critical Care Medicine·Toshiyuki KoyaErwin W Gelfand

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Jan 20, 2009·American Journal of Respiratory Cell and Molecular Biology·Toshiyuki KoyaErwin W Gelfand
Jul 16, 2011·American Journal of Respiratory Cell and Molecular Biology·Yasuko FuchimotoMitsune Tanimoto
Jul 19, 2006·American Journal of Respiratory Cell and Molecular Biology·Mitchell H Grayson, Michael J Holtzman
Oct 5, 2013·Expert Opinion on Therapeutic Targets·Rafael Elias MarquesMauro Martins Teixeira
Jun 18, 2011·The Journal of Allergy and Clinical Immunology·Stephanie BrandHarald Renz
Apr 21, 2007·The Journal of Allergy and Clinical Immunology·Ildikó UngváriCsaba Szalai
Dec 18, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M HayashiF Gejyo
Aug 23, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H KawakamiI Narita
Jan 17, 2019·American Journal of Respiratory Cell and Molecular Biology·Sandra RuttingBrian G Oliver
Jul 14, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anthony JoethamErwin W Gelfand
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