RANTES gene polymorphisms (-403G>A and -28C>G) associated with hepatitis B virus infection in a Saudi population

Genetics and Molecular Research : GMR
A Al-QahtaniF N Almajhdi

Abstract

Besides the host immune response, genetic and environmental factors play crucial roles in the manifestation of hepatitis B virus (HBV) infection. "Regulated on activation normal T-cell expressed and secreted" factor (RANTES) plays a vital role in CD4(+), CD8(+) T-lymphocyte and dendritic cell activation and proliferation in inflammation. Single nucleotide polymorphisms (SNPs) in the RANTES gene are associated with several viral and non-viral diseases. Association studies have invariably indicated a lack of association between RANTES gene SNPs and HBV infection in ethnic populations, even though RANTES gene SNPs exhibit distinct ethnic distributions. Despite the high prevalence of HBV infections in Saudi Arabia, no studies have been made concerning a possible relationship between RANTES gene polymorphisms and susceptibility to and progression of HBV infection. We examined -403G>A and -28C>G RANTES gene variants in 473 healthy controls and 484 HBV patients in ethnic Saudi populations. Significant differences were found in the genotype and allele distributions of the SNPs between the controls and the HBV patients. Both SNPs were significantly linked to viral clearance in these subjects. Our data demonstrate for the first time in a...Continue Reading

References

Apr 1, 1996·The Journal of Clinical Investigation·B RehermannF V Chisari
Dec 11, 1997·The New England Journal of Medicine·W M Lee
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·H LiuT Shioda
Jan 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·R G NickelS K Huang
Jul 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ping AnCheryl A Winkler
Sep 3, 2002·American Journal of Respiratory and Critical Care Medicine·Nobuyuki HizawaMasaharu Nishimura
Oct 11, 2002·Proceedings of the National Academy of Sciences of the United States of America·Enrique GonzalezSunil K Ahuja
Oct 25, 2003·Science·Arash GrakouiChristopher M Walker
Dec 3, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Simon HellierAdrian V S Hill
Jul 22, 2004·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·X-Y ZhaoB J Zheng
Nov 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Traci L NessSteven L Kunkel
Jun 9, 2005·The Journal of Experimental Medicine·David G Bowen, Christopher M Walker
Jan 5, 2007·Experimental & Molecular Medicine·Byung Lae ParkHyoung Doo Shin
Nov 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chloe L ThioMary Carrington
Nov 26, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David Durantel, Fabien Zoulim
Dec 30, 2009·Leukemia & Lymphoma·Paige M BracciJohn K Wiencke
May 1, 2010·Archives of Medical Research·Yong-Gang ZhangHong Fan
Sep 28, 2010·The Journal of Pediatrics·Sonia CentiLina Artifoni

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Citations

Jun 27, 1989·Biochimica Et Biophysica Acta·M S Shet, M Madaiah
Jul 4, 2013·The International Journal of Biochemistry & Cell Biology·Bo LiuYuquan Wei
Dec 11, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Juwon KimKyung-A Lee
Nov 26, 2013·Acta Biochimica Et Biophysica Sinica·Qiaoli LiuMin Zheng
Nov 20, 2016·Journal of Clinical Laboratory Analysis·Nasimudeen R JabirShams Tabrez

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