RANTES in onchocerciasis: changes with ivermectin treatment

Clinical and Experimental Immunology
P J CooperG E Griffin

Abstract

Adverse reactions are seen relatively frequently after treatment of onchocerciasis patients with ivermectin. The chemokines RANTES and IL-8, which have both chemotactic and activation properties for eosinophils and neutrophils, respectively, may have a role in the pathogenesis of post-treatment reactions. Circulating levels of the chemokines and the cytokines tumour necrosis factor-alpha (TNF-alpha) and IL-6 were measured in the plasma of 22 Onchocerca volvulus-infected subjects. Peaks of mean circulating levels of RANTES and TNF-alpha were seen at 6 h after ivermectin administration. Peripheral eosinophil counts declined at 36 h post-treatment and an early peak in RANTES levels was associated with a delay in peripheral eosinopenia. RANTES levels were negatively correlated with severity of rash (P < 0.001) and lymphoedema (P < 0.05), suggesting that high circulating levels of RANTES may inhibit eosinophil sequestration. No changes in circulating levels of IL-8 were seen. These findings suggest a possible role of circulating RANTES in modulating eosinophil sequestration in vivo.

Citations

Oct 5, 2001·Clinical Microbiology Reviews·S W Chensue
Dec 22, 1999·Infection and Immunity·R GopinathT B Nutman
Nov 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yovany MorenoTimothy G Geary
Dec 29, 2011·Microbes and Infection·Christian J LechnerPeter T Soboslay
Oct 20, 2005·Clinical and Experimental Immunology·J FendtP T Soboslay
May 4, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·P J CooperT B Nutman

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