Abstract
RANTES (regulated upon activation normal T expressed and secreted) is another member of the intercrine beta subfamily which acts as a selective chemoattractant for human monocytes and CD4-positive lymphocytes and increases the adherence of monocytes to endothelial cells. In this work, the effect of RANTES was studied on rat skin injection sites. Rats were intradermally injected with 50 microliters of RANTES, at different concentrations, fMet-Leu-Phe (FMLP), or LPS (positive controls) or PBS vehicle (negative control). The animals were then injected with 0.6 ml of Evans' blue in the tail vein in order to obtain a blue colour in the areas where the compounds were injected. After 4 h the rats were killed and the maximum diameter of the blue extravasation area was measured. The coloured areas were then excised and optical and electron microscopic studies were performed. In addition, in some of the excised tissue, a Northern blot analysis for histidine decarboxylase (HDC) mRNA was performed along with an estimation of the amount of histamine generated in the tissue injection sites. In these studies it was found that intradermal injections of 5, 2.5, and 1.25 x 10(-5) M RANTES produced a strong inflammatory response with the accumula...Continue Reading
References
Nov 24, 1979·Nucleic Acids Research·H C Birnboim, J Doly
Dec 1, 1992·The Journal of Experimental Medicine·A RotC A Dahinden
Mar 1, 1992·Immunology Letters·P ContiR A Dempsey
Oct 18, 1990·Nature·T J SchallD V Goeddel
Jan 1, 1991·Annual Review of Immunology·J J OppenheimK Matsushima
Mar 1, 1991·The Journal of Experimental Medicine·A B KayQ Hamid
Oct 1, 1989·The Journal of Experimental Medicine·N Matsuura, B R Zetter
Jan 4, 1980·Science·T C TheoharidesW W Douglas
May 20, 1982·Nature·T C TheoharidesP W Askenase
Dec 1, 1993·The Journal of Experimental Medicine·R MeurerH Rosen
May 1, 1994·The Journal of Experimental Medicine·O DevergneT Kim
Jan 1, 1995·European Journal of Immunology·M UguccioniM Baggiolini
Jun 1, 1995·The Journal of Experimental Medicine·S YingA B Kay
Jun 6, 1995·Biochemical and Biophysical Research Communications·T N WellsK B Bacon
Mar 1, 1993·European Journal of Immunology·S C BischoffC A Dahinden
Mar 1, 1994·Immunology Today·M Baggiolini, C A Dahinden
Jan 28, 1993·The New England Journal of Medicine·S J Galli
Citations
Dec 28, 2006·Neuroimmunomodulation·Maria Luisa CastellaniJacopo Vecchiet
Dec 19, 1998·British Journal of Haematology·P ContiT C Theoharides
Nov 25, 2000·Journal of Hematotherapy & Stem Cell Research·A WallerL G Czaplewski
Mar 18, 2010·Expert Opinion on Biological Therapy·Natalia Lapteva, Xue F Huang
Aug 13, 2004·Veterinary Dermatology·R MarsellaJ Lopez
Nov 20, 2012·Oncoimmunology·Gabriele CantiniSerena Pellegatta
Dec 2, 2015·Geriatric Orthopaedic Surgery & Rehabilitation·Alasdair G SutherlandJanet Liversidge
Dec 14, 2006·Calcified Tissue International·M L CastellaniP Conti
Nov 6, 2007·Breast Cancer Research and Treatment·Mevan M JayasingheRobert A Kurt
Dec 5, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P ContiT C Theoharides
Aug 28, 2013·Diabetologia·Bo LiuShanta J Persaud
Sep 14, 2017·Molecular Medicine Reports·Kai SunHuifeng Zheng
Jan 10, 2006·The International Journal of Biological Markers·C TrakatelliJ Vecchiet
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A HeinemannI Sabroe
Oct 28, 2020·Acta Neurologica Scandinavica·Lukas HolmegaardChristina Jern