Abstract
The RAP55 protein family is evolutionarily conserved in eukaryotes. Two highly conserved paralogues, RAP55A and RAP55B, exist in vertebrates; their functional properties and expression patterns remain to be compared. RAP55 proteins share multiple domains: the LSm14 domain, a serine/threonine rich region, an FDF (phenylalanine-aspartate-phenylalanine) motif, an FFD-TFG box and RGG (arginine-glycine-glycine) repeats. Together these domains are responsible for RAP55 proteins participating in translational repression, incorporation into mRNP particles, protein-protein interactions, P-body formation and stress granule localisation. All RAP55A proteins localise to P-body-like complexes either in the germline or in somatic cells. Xenopus laevis RAP55B has been shown to be part of translationally repressed mRNP complexes in early oocytes. Together these findings suggest that this protein family has evolved a common and fundamental role in the control of mRNA translation. Furthermore human RAP55A is an autoantigen detected in the serum of patients with primary biliary cirrhosis (PBC). The link between RAP55A, P-bodies and PBC remains to be elucidated.
References
Jul 29, 1994·Science·C G Burd, G Dreyfuss
Dec 16, 1998·Experimental Cell Research·B LiebU Scheer
Jul 1, 2004·FEBS Letters·Mario Albrecht, Thomas Lengauer
Jul 30, 2005·Trends in Biochemical Sciences·Permanan KhusialGary W Zieve
Oct 14, 2005·Development·Peter R BoagT Keith Blackwell
Oct 26, 2005·The Journal of Cell Biology·Anjon AudhyaKaren Oegema
Nov 1, 2005·Developmental Cell·James E WilhelmSuzanne Sayles
Dec 24, 2005·The New England Journal of Medicine·Giuseppe BrancatelliArye Blachar
Feb 18, 2006·RNA·Wei-Hong YangDonald B Bloch
Apr 26, 2006·The Journal of Cell Biology·Carolyn J Decker, Roy Parker
Jun 14, 2006·Nucleic Acids Research·Andrew Weston, John Sommerville
Dec 22, 2006·Nature Reviews. Molecular Cell Biology·Ana EulalioElisa Izaurralde
Mar 7, 2007·RNA·Wei-Hong Yang, Donald B Bloch
Mar 14, 2007·Molecular Cell·Roy Parker, Ujwal Sheth
Sep 18, 2007·RNA Biology·Katherine S Godin, Gabriele Varani
Citations
May 22, 2009·The Journal of Biological Chemistry·Patrick K ArthurTomas Pieler
May 17, 2013·Molecular Biology of the Cell·Timothy KrügerSusanne Kramer
Sep 17, 2010·Genes & Development·Yuying WangPhillip A Newmark
Nov 25, 2011·Development, Growth & Differentiation·Yasuko Kato, Akira Nakamura
Sep 14, 2012·Journal of Virology·Bobo Wing-Yee MokHonglin Chen
Mar 24, 2012·BMC Bioinformatics·Maria SecrierReinhard Schneider
Jun 2, 2015·Cell Reports·Tamiko NishimuraMarc R Fabian
Jul 23, 2013·Veterinary Immunology and Immunopathology·Guilan WenWeihuan Fang
Oct 4, 2013·The Biochemical Journal·Marina CristoderoIsabel Roditi
May 18, 2010·Developmental Biology·Yoriko NakamuraKen Matsumoto
May 23, 2012·RNA Biology·Ken MatsumotoMasafumi Tsujimoto
Feb 9, 2013·RNA Biology·Carol J Wilusz, Jeffrey Wilusz
Oct 13, 2015·Biochimica Et Biophysica Acta·Michael Ladomery, John Sommerville
Oct 25, 2016·PloS One·Pham Thi Kim LienKenji Irie
Jun 20, 2017·PLoS Pathogens·Susanne Kramer
May 24, 2018·Wiley Interdisciplinary Reviews. RNA·Debadrita Roy, Purusharth I Rajyaguru
Dec 21, 2017·Parasites & Vectors·Paola A NocuaConcepción J Puerta
Feb 27, 2018·ELife·Masatoshi HaraTerry L Orr-Weaver
Mar 8, 2018·The EMBO Journal·Tobias BrandmannMartin Jinek
Nov 4, 2015·BMC Genomics·B P Niranjan ReddyScott E Lindner
May 3, 2018·Scientific Reports·Karl-Frédéric Vieux, Hugh J Clarke
Dec 12, 2018·PLoS Genetics·Quira ZeidanAlan G Hinnebusch
Sep 20, 2019·The Journal of Veterinary Medical Science·Lang TianChanghong Li
Mar 19, 2020·Cells·Marie Christou-KentChristophe Arnoult
Oct 24, 2018·Developmental Biology·Eugenia C OlesnickyDarrell J Killian
Jul 11, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Li ZhangZhiwei Wu