Rapamycin Attenuates Age-associated Changes in Tibialis Anterior Tendon Viscoelastic Properties

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Lauren Wood ZaseckSusan V Brooks

Abstract

Rapamycin extends mouse life span, but the extent to which rapamycin prevents aging-associated changes in specific tissues remains unclear. Stiffness increases and collagen turnover decreases in mouse tendon with aging; thus, our aim was to determine the effect of long-term rapamycin treatment on the mechanical and structural properties of tendons from old mice. Tendons were harvested from female UM-HET3 mice maintained on a standard chow diet for 4 (adult) or 22 (old) months or fed chow containing polymer-encapsulated rapamycin (eRAPA) from 9 to 22 months of age (old RAPA). Stiffness was twofold higher for tendons of old compared with adult mice, but in old RAPA mice, tendon stiffness was maintained at a value not different from that of adults. Additionally, expression of collagen decreased, expression of matrix metalloproteinase-8 increased, and total hydroxyproline content trended toward decreased levels in tendons of old eRAPA-fed mice compared with controls. Finally, age-associated calcification of Achilles tendons and accompanying elevations in expression of chondrocyte and osteoblast markers were all lower in old eRAPA-fed mice. These results suggest that long-term administration of rapamycin alters the molecular pathway...Continue Reading

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May 22, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Sebastian I Arriola Apelo, Dudley W Lamming
Dec 8, 2017·Scientific Reports·Joohyun LimKyu Sang Joeng
Oct 20, 2018·Current Stem Cell Research & Therapy·Yingjuan LiYunfeng Rui
Jul 30, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Theresa MauRaymond Yung
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Nov 25, 2020·Annals of the New York Academy of Sciences·Apratim BajpaiWeiqiang Chen
Apr 16, 2021·Frontiers in Cell and Developmental Biology·Minhao ChenYunfeng Rui

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