Rapamycin loaded magnetic Fe3O4/carboxymethylchitosan nanoparticles as tumor-targeted drug delivery system: Synthesis and in vitro characterization

Colloids and Surfaces. B, Biointerfaces
Guiyin LiYongxiang Zhao

Abstract

A novel tumor-targeted drug delivery system (Fe3O4/CMCS-Rapa NPs) was prepared using magnetic Fe3O4/carboxymethylchitosan nanoparticles (Fe3O4/CMCS NPs) as carrier and rapamycin (Rapa) as the model anti-tumor drug. The morphology, composition, and properties of the Fe3O4/CMCS-Rapa NPs were characterized by Fourier transform infrared spectroscopy (FT-IR), transmission electron microscope (TEM), X-ray diffraction (XRD), thermal analysis (TG/DSC), vibration sample magnetometer (VSM), and drug release kinetics, cytotoxicity, cellular uptake, apoptosis studies in vitro. The results showed that the synthesized Fe3O4/CMCS-Rapa NPs were spherical in shape with an average size of 30±2 nm, the saturated magnetization reached 67.1 emu/g, and the loading efficiency of Rapa was approximately 6.32±0.34%. In addition, the in vitro drug release behavior displayed that the Fe3O4/CMCS NPs exhibited a biphasic drug release pattern with initial burst release and consequently sustained release. Furthermore, the Fe3O4/CMCS-Rapa NPs showed lower cytotoxicity to liver cell line (LO2) and comparatively higher cytotoxicity to human hepatocarcinoma cell line (HepG2) than native Rapa. Fe3O4/CMCS-Rapa NPs could enhance cellular uptake and reduce Rapa drug ...Continue Reading

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Citations

Aug 15, 2015·Biochemical and Biophysical Research Communications·Rainer TietzeChristoph Alexiou
May 30, 2015·Physical Chemistry Chemical Physics : PCCP·Karrina McNamara, Syed A M Tofail
Aug 18, 2016·International Journal of Pharmaceutics·Mahsa Ghassemi Nooreini, Homayon Ahmad Panahi
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Jun 29, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Roxana Cristina PopescuDiana Savu
Jul 11, 2019·Nanoscale Research Letters·Siwen WuYongxiang Zhao
Nov 21, 2018·Documenta Ophthalmologica. Advances in Ophthalmology·Mayara Rodrigues Brandão De PaivaArmando Silva-Cunha
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Nov 4, 2020·Critical Reviews in Analytical Chemistry·Karen Cristina Dos SantosMarlus Chorilli
Nov 26, 2019·Materials Science & Engineering. C, Materials for Biological Applications·Kebede K KefeniBhekie B Mamba

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