PMID: 14550466Oct 11, 2003Paper

Rapamycin preserves renal function compared with cyclosporine A after ischemia/reperfusion injury

Urology
Sharon R InmanJennifer L Seminerio

Abstract

To determine the effect of cyclosporine and rapamycin administration on renal function after ischemia/reperfusion injury (I/R). Cyclosporine A has known nephrotoxic effects. Thus, cyclosporine therapy subsequent to I/R injury may further exacerbate graft dysfunction. Rapamycin is a newer agent that suppresses the immune system by a different mechanism. Male Wistar rats (250 g) were anesthetized, and the suprarenal aorta was clamped for 40 minutes. The right kidney was removed. After recovery, the rats were divided into four groups: group 1, controls, no ischemia and no treatment (n = 10); group 2, ischemia with no treatment (n = 8); group 3, ischemia plus rapamycin (0.17 mg/kg/day gavage, n = 8); and group 4, ischemia plus cyclosporine A (30 mg/kg/day intraperitoneally, n = 9). The glomerular filtration rate was measured 5 to 7 days after I/R injury using urinary iohexol clearance. Data are expressed as the mean +/- SEM, and intergroup comparisons were made using one-way analysis of variance. The mean GFR value for the controls (no ischemia, no treatment) was 1.23 +/- 0.08 mL/min; for group 2 (ischemia, no treatment), it was 1.05 +/- 0.10 mL/min; for group 3 (ischemia plus rapamycin) 1.06 +/- 0.14 mL/min; and for group 4 (ische...Continue Reading

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Citations

Nov 12, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Graciela Martinez-PalliClaus U Niemann
Aug 2, 2007·Transplantation·Emilio D PoggioStuart M Flechner
Aug 1, 2012·PloS One·Kechen Ban, Rosemary A Kozar
Oct 27, 2009·Digestive Diseases and Sciences·Yuan-Xing LiuShu-Sen Zheng
Dec 7, 2006·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Gopala K Rangan
Feb 23, 2010·Transplantation Proceedings·C ParraJ Dominguez
Sep 12, 2006·Transplant International : Official Journal of the European Society for Organ Transplantation·Sing Leung LuiTak Mao Chan
Apr 21, 2009·Pharmacology & Therapeutics·Gopala K RanganKok On Ho
Sep 15, 2012·European Journal of Pharmacology·Mahmoud M El-MasAmal G Omar
Apr 1, 2011·Current Therapeutic Research, Clinical and Experimental·Tamer SagirogluMehmet Ali Yagci
Aug 2, 2016·Nature Reviews. Nephrology·Daniel FantusAngus W Thomson
Jun 16, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·B J PereiraL Yu
Sep 30, 2010·Acta Cirúrgica Brasileira·Hulya OzturkAysel Kukner
Dec 21, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Sudhir S KushwahaBrooks S Edwards
Oct 17, 2019·Acta Cirúrgica Brasileira·Antonio Carlos Cerqueira OliveiraPaulo Adriano Schwingel
Jun 3, 2021·International Journal of Molecular Sciences·Maria NamwanjeAmandeep Bajwa
Jun 15, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Morteza Ghasemnejad-BerenjiAhmad Reza Dehpour

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