Rapamycin prevents the development of nephritis in lupus-prone NZB/W F1 mice

Lupus
S L LuiTak Mao Chan

Abstract

Rapamycin is a potent immunosuppressive drug currently used mainly for rejection prophylaxis in renal transplantation. The aim of this study was to determine the effect of rapamycin treatment on the development of nephritis in lupus-prone New Zealand Black/White F1 (NZB/W F1) mice. Twelve-week-old female NZB/W F1 mice were treated with rapamycin (3 mg/kg body weight) or saline once daily by oral gavage for 20 weeks. The severity of nephritis was assessed by clinical and biochemical parameters, renal histology, immunohistochemistry and gene expression studies. Rapamycin treatment markedly reduced proteinuria, improved renal function, decreased serum anti-double stranded DNA antibody levels and diminished splenomegaly. Kidney sections from saline-treated mice showed marked mesangial proliferation, tubular dilation with protein cast deposition and interstitial inflammatory cell infiltration. Rapamycin-treated mice had near normal renal histology, with marked reduction in glomerular immune deposition and the infiltration by T cells, B cells and macrophages. Rapamycin treatment was associated with down-regulation of intra-renal expression of monocyte chemoattractant protein-1 (MCP-1) mRNA and protein. We conclude that rapamycin is h...Continue Reading

References

Jun 1, 1978·Arthritis and Rheumatism·F J DixonC B Wilson
Jan 1, 1968·Advances in Immunology·J B Howie, B J Helyer
May 1, 1997·Journal of the American Society of Nephrology : JASN·C ZojaG Remuzzi
Aug 11, 1998·Journal of the American Society of Nephrology : JASN·M C Van BruggenJ H Berden
Apr 24, 2001·Journal of the American Society of Nephrology : JASN·Hans-Joachim AndersDetlef Schlöndorff
Jun 28, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S YungJ R Couchman
Feb 5, 2002·Expert Opinion on Pharmacotherapy·B D Kahan
Apr 19, 2002·Journal of the American Society of Nephrology : JASN·Tak-Mao ChanSusan Yung
Oct 10, 2002·American Journal of Physiology. Renal Physiology·Gunter WolfRolf A K Stahl
Nov 28, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Christiane Viedt, Stephan R Orth
May 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Koji KinoshitaAkihisa Kanamaru
Dec 17, 2004·Journal of the American Society of Nephrology : JASN·Brad H RovinHaikady N Nagaraja
Feb 25, 2005·Journal of the American Society of Nephrology : JASN·Tak-Mao ChanUNKNOWN Hong Kong Nephrology Study Group
Mar 25, 2005·Journal of the American Society of Nephrology : JASN·Jian-Kang ChenRaymond C Harris
May 27, 2005·Journal of the American Society of Nephrology : JASN·Ramon G B BonegioWilfred Lieberthal
Oct 21, 2005·Journal of the American Society of Nephrology : JASN·Giovanni StalloneGiuseppe Grandaliano
Mar 15, 2006·Seminars in Nephrology·Neerja AgrawalIan R Rifkin
May 30, 2006·Kidney International·M-J WuM-J Tang
Aug 25, 2006·Kidney International·M Waldman, G B Appel
Feb 20, 2007·Lancet·David P D'CruzGraham R V Hughes
Feb 27, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Kun L MaZac Varghese

❮ Previous
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Citations

Feb 9, 2010·Cellular & Molecular Immunology·Abigail PeairsChristopher M Reilly
Jan 16, 2013·Immunology and Cell Biology·Sarah A JonesJames Harris
Aug 17, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kostas StylianouEugene Daphnis
Feb 1, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kostas StylianouEugene Daphnis
Nov 5, 2008·Arthritis Research & Therapy·Padmalatha S ReddyMargot O'Toole
Mar 24, 2006·AJR. American Journal of Roentgenology·Anthony J YunAnthony N Gerber
Mar 23, 2013·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Namrata SinghPhilip L Cohen
Feb 13, 2010·Expert Opinion on Emerging Drugs·Chi Chiu Mok
Dec 25, 2015·Nature Reviews. Rheumatology·Andras Perl
Jul 28, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Tiffany N CazaAndras Perl
Jan 13, 2012·Annals of the New York Academy of Sciences·Mindy S Lo, George C Tsokos
Sep 27, 2013·Clinical & Developmental Immunology·Stavros StratakisEugene Daphnis
Apr 21, 2009·Pharmacology & Therapeutics·Gopala K RanganKok On Ho
Nov 20, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Anastasia Markopoulou, Vasileios C Kyttaris
Nov 26, 2014·Nature Reviews. Nephrology·Tak Mao Chan
Aug 2, 2016·Nature Reviews. Nephrology·Daniel FantusAngus W Thomson
Sep 3, 2016·Apoptosis : an International Journal on Programmed Cell Death·Joanna Kabat-KoperskaKazimierz Ciechanowski
Sep 30, 2016·Thrombosis and Haemostasis·Moanaro BiswasRoland W Herzog
Nov 2, 2016·The Journal of Clinical Investigation·Derek D JonesDavid Allman
Oct 3, 2018·The Journal of Rheumatology·Desmond Y H YapTak Mao Chan
Jul 31, 2019·Clinical Science·Chenzhu ZhangTak Mao Chan
Jan 26, 2018·Transplantation·Maggie K M MaTak Mao Chan
Feb 23, 2019·Frontiers in Pharmacology·Per ErikssonChristopher Sjöwall
Jun 12, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Karolina KędzierskaKazimierz Ciechanowski
Dec 2, 2020·International Journal of Molecular Sciences·Claudia M Trujillo-VargasCintia S de Paiva
Nov 13, 2020·Clinical Reviews in Allergy & Immunology·Tingting WangXuan Zhang
Apr 11, 2021·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Hong-Tai Tzeng, I-Tsu Chyuan
Jun 19, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Paramarajan Piranavan, Andras Perl
Jun 25, 2021·Frontiers in Immunology·Iwan G A Raza, Alexander J Clarke

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