PMID: 8971030Dec 1, 1996Paper

Rapamycin stimulates viral protein synthesis and augments the shutoff of host protein synthesis upon picornavirus infection

Journal of Virology
L BerettaNahum Sonenberg

Abstract

The immunosuppressant drug rapamycin blocks progression of the cell cycle at G1 in mammalian cells and yeast. We recently showed that rapamycin inhibits both in vitro and in vivo cap-dependent, but not cap-independent, translation. This inhibition is causally related to reduced phosphorylation and consequent activation of 4E-BP1, a repressor of the function of the cap-binding protein, eIF4E. Two members of the picornavirus family, encephalomyocarditis virus and poliovirus, inhibit phosphorylation of 4E-BP1. Since translation of picornavirus mRNAs is cap independent, inhibition of phosphorylation of 4E-BP1 could contribute to the shutoff of host protein synthesis. Here, we show that rapamycin augments both the shutoff of host protein synthesis and the initial rate of synthesis of viral proteins in cells infected with encephalomyocarditis virus and poliovirus.

References

Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·G W BothA J Shatkin
Jun 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·Y KaufmannS Penman
Dec 1, 1990·Trends in Biochemical Sciences·R J JacksonA Kaminski
Jan 1, 1987·Advances in Virus Research·N Sonenberg
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·L M GravesJ C Lawrence
Jan 13, 1995·The Journal of Biological Chemistry·C J SabersR T Abraham
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·C HuJ C Lawrence
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·A C GingrasN Sonenberg
Jan 1, 1996·Molecular Biology of the Cell·N C BarbetM N Hall

❮ Previous
Next ❯

Citations

Jun 29, 2000·Annual Review of Biochemistry·A C GingrasN Sonenberg
Apr 12, 2002·The Journal of Biological Chemistry·Annabelle GrolleauLaura Beretta
Sep 27, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zachary R ShaheenJohn A Corbett
Aug 30, 2020·Nature Communications·Piero GiansantiFrank J M van Kuppeveld
Jun 6, 2000·Microbiology and Molecular Biology Reviews : MMBR·M GaleM G Katze
Mar 6, 2003·The Journal of Biological Chemistry·Malvyne Rolli-DerkinderenMichel Dy
Oct 15, 2003·The Journal of Biological Chemistry·Francis PoulinNahum Sonenberg
Jul 6, 2000·Molecular Cell·S PyronnetN Sonenberg
Oct 12, 2007·Biochemical and Biophysical Research Communications·Kazuhiro NishimuraKazuei Igarashi
Jan 5, 2002·Science·Yohei MaeshimaRaghu Kalluri
Apr 12, 2001·Genes & Development·A C GingrasN Sonenberg
Aug 18, 2004·Genes & Development·Nissim Hay, Nahum Sonenberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.