Rapid action of Qinghaosu and related drugs on incorporation of [3H]isoleucine by Plasmodium falciparum in vitro.

Biochemical Pharmacology
H M GuW Peters

Abstract

Using the incorporation of [3H]isoleucine into acid-insoluble products as an index of protein-synthetic activity, it was shown that Qinghaosu and two related drugs had a rapid effect on this process in human erythrocytes infected with Plasmodium falciparum in vitro. Inhibition could be seen 1 hr or less after addition of the drugs at concentrations from 5 mumole/1. to 50 nmole/1. It is recommended that the effects of these drugs be studied in cell-free protein-synthetic systems.

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Citations

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Sep 1, 1989·Antimicrobial Agents and Chemotherapy·S H Xiao, B A Catto
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Jun 6, 2002·Memórias do Instituto Oswaldo Cruz·Ana FerrerasFlor Herrera
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May 5, 2000·The Cochrane Database of Systematic Reviews·H M McIntosh, P Olliaro
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Oct 1, 1987·Annals of Tropical Medicine and Parasitology·W Trager
Sep 16, 1992·Biochemical and Biophysical Research Communications·N Surolia, G Padmanaban

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