Rapid activation of JNK1 in UV-B irradiated epidermal keratinocytes

Oncogene
N T RamaswamyJ C Pelling

Abstract

Jun N-terminal kinase (JNK1) is a member of a family of stress-activated protein kinases which are activated by many forms of stress including UV radiation, resulting in the phosphorylation of c-Jun, ATF-2, Elk-1 and p53. As UV-B radiation is mainly responsible for ultraviolet (UV)-induced skin cancers, we chose to elucidate JNK1 activation in keratinocytes which represent a UV-relevant cell system. We have demonstrated rapid activation of JNK1 in a keratinocyte cell line, C50, in response to multiple doses of UV-B irradiation. JNK1 activation occurred within 1 min, peaked by 10 min and returned to near basal levels within 2 h following the UV-B treatments. Our data provide the first evidence to show that keratinocytes do respond to multiple doses of the physiologically relevant UV-B radiation through rapid activation of the JNK1 pathway.

Citations

Mar 29, 2001·International Journal of Cancer. Journal International Du Cancer·A Ruhland, E M de Villiers
Mar 17, 2004·Toxicology and Applied Pharmacology·Diane E HeckJeffrey D Laskin
Jan 10, 2003·The Journal of Investigative Dermatology. Symposium Proceedings·Brian J NickoloffMitchell F Denning
Feb 6, 2008·Zebrafish
Feb 6, 2008·Photochemistry and Photobiology·Janine G EinspahrSteven P Stratton
Aug 30, 2003·Photochemistry and Photobiology·Rozen Le PanseBernard Coulomb
Dec 24, 2010·European Journal of Cell Biology·Kathrin KoehlerEhrhardt Proksch
Jun 2, 2010·Biochemical and Biophysical Research Communications·Kentaro MeraTakuro Kanekura
Aug 22, 2000·The Journal of Investigative Dermatology·J W WongR R Isseroff
Aug 3, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yoko Inès NozawaPao-Tien Chuang
Nov 6, 2002·Biochemical Pharmacology·Runa SurJeffrey D Laskin
Oct 23, 2008·Biochemical and Biophysical Research Communications·Masahiro IwataIkuro Maruyama
Jul 11, 2006·Journal of Dermatological Science·Chika KatagiriToshihiko Hibino
May 2, 2006·The Journal of Biological Chemistry·Alix GazelMiroslav Blumenberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.