Rapid activation of the complement system by cuprophane depends on complement component C4

Kidney International
K LhottaP König

Abstract

Hemodialysis with cuprophane dialyzer membranes promotes rapid activation of the complement system, which is thought to be mediated by the alternative pathway. Complete hereditary deficiency of complement C4, a classical pathway component, in two hemodialysis patients provided the opportunity to investigate a possible role of the classical pathway. In two hemodialysis patients with both C4 isotypes, C4A and C4B, and in one patient with C4B deficiency complement activation occurred immediately after the onset of hemodialysis, with peak levels of C3a and terminal complement complex (TCC) after ten to fifteen minutes. In patients with complete C4 deficiency, C3a and TCC remained unchanged for fifteen minutes and increased thereafter, reaching the highest level after thirty minutes. The leukocyte nadir was also delayed from fifteen to thirty minutes. In vitro incubation of normal, C4A- or C4B-deficient serum with cuprophane caused complement activation after fifteen minutes. In contrast, no activation was observed in sera of four C4-deficient patients. The addition of normal serum or purified human C4 restored the capacity for rapid complement activation. In one patient with severe immunoglobulin deficiency, C3a and TCC levels incr...Continue Reading

References

Apr 7, 1977·The New England Journal of Medicine·P R CraddockH S Jacob
Feb 1, 1992·Journal of the American Society of Nephrology : JASN·A K CheungE Brynda
Dec 1, 1992·Journal of the American Society of Nephrology : JASN·J C HornbergerA M Garber
Oct 31, 1991·Klinische Wochenschrift·T Strasser, H Schiffl
Jan 1, 1991·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·F Maillet, M D Kazatchkine
Mar 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J HimmelfarbR Hakim
Nov 1, 1986·The Biochemical Journal·E Sim, S J Cross
Mar 25, 1968·JAMA : the Journal of the American Medical Association·L S Kaplow, J A Goffinet
Oct 4, 1984·The New England Journal of Medicine·R M HakimF K Port
Dec 1, 1983·Kidney International·D E ChenowethL W Henderson
Sep 1, 1993·Kidney International·R M Hakim
Feb 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R M Hakim, N Levin

❮ Previous
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Citations

Sep 13, 2001·Journal of Biomedical Materials Research·J WetteröP Tengvall
Jan 17, 2002·Biomaterials·Jonas WetteröPentti Tengvall
Aug 14, 2003·Molecular Immunology·L A TrouwM R Daha
Dec 22, 1998·The Journal of Experimental Medicine·D MevorachK B Elkon
Dec 3, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hendrik KollerAlexander R Rosenkranz
Jan 24, 2006·Blood Purification·Takayuki SohkaKenji Kasai
Mar 27, 2001·Journal of Biomaterials Science. Polymer Edition·M V SeftonM B Gorbet
Mar 27, 2001·Journal of Biomaterials Science. Polymer Edition·C H Gemmell
Jun 3, 1999·Clinical Chemistry and Laboratory Medicine : CCLM·G F KörmöcziG J Zlabinger
Jul 2, 2003·Journal of Biomedical Materials Research. Part a·Jonas WetteröTorbjörn Bengtsson
Feb 4, 2010·Acta Biomaterialia·Mitsuaki TodaHiroo Iwata
Feb 24, 2009·Biochemical and Biophysical Research Communications·Dorthe B CorlinNiels H H Heegaard
Oct 24, 2007·Biomaterials·Mitsuaki TodaHiroo Iwata
Jun 27, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Tejesh S PatelGil Yosipovitch
Oct 13, 2007·European Journal of Clinical Investigation·K HocheggerM Rudnicki
Jun 8, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Andrey SokolovTom E Mollnes
Aug 15, 2006·Molecular Immunology·Bo NilssonJohn D Lambris
Feb 5, 2015·Translational Stroke Research·Mingzhe ZhengYa Hua
Oct 14, 2010·Biochemical and Biophysical Research Communications·Dorthe B CorlinNiels H H Heegaard
Feb 26, 2015·Clinical Kidney Journal·Shan HuangKristina N Ekdahl
Feb 28, 2017·Nature Reviews. Nephrology·Kristina N EkdahlBo Nilsson
Mar 27, 2018·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Randolf HardersenAnders Hovland
Jun 20, 2018·Macromolecular Bioscience·Guoying Zhou, Thomas Groth
Apr 28, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mariana Gaya da CostaMarc A Seelen
Apr 6, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ioannis KourtzelisJohn D Lambris
Feb 23, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·You-Qiang WuJohn D Lambris
Feb 10, 2018·Frontiers in Immunology·Felix PoppelaarsMarc A Seelen
Aug 7, 2019·Current Opinion in Organ Transplantation·Andrea AngelettiPaolo Cravedi
Apr 17, 2020·Frontiers in Immunology·Karin FromellBo Nilsson
Dec 15, 2020·Biomaterials·Cassie BennettAbhishek Prasad
Apr 3, 2021·International Orthopaedics·Cristian Paul DanGheorghe Tomoaia
Apr 13, 2010·ACS Applied Materials & Interfaces·Mitsuaki Toda, Hiroo Iwata

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