Rapid, activity-dependent plasticity in timing precision in neonatal barrel cortex.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Michael I DawJ T Isaac

Abstract

Developing neuronal networks acquire the ability to precisely time events, a key feature required for information processing. In the barrel cortex, encoding of information requires a high-precision temporal code with a resolution of approximately 5 ms; however, it is not known what process drives the maturation in timing precision. Here, we report that long-term potentiation (LTP) at thalamocortical synapses in the neonatal layer IV barrel cortex produces a dramatic improvement in the timing of neuronal output and synaptic input. LTP strongly reduces the latency and variability of synaptically evoked action potentials, improving the fidelity of timing to within that predicted to be required for adult sensory processing. Such changes in timing also occur during development in the neonate. LTP also reduces the summation of EPSPs shortening the window for coincidence detection for synaptic input. In contrast to these reliable effects, LTP produced only a modest and variable change in synaptic efficacy. Thus, our findings suggest that the primary role of this form of neonatal LTP is for the acquisition of timing precision and the refinement of coincidence detection, rather than an increase in synaptic strength. Therefore, neonatal ...Continue Reading

Citations

Jan 8, 2013·Nature Neuroscience·Andres De la RossaDenis Jabaudon
Jul 30, 2008·Cerebral Cortex·Marat MinlebaevRoustem Khazipov
Aug 19, 2010·Pharmacological Reviews·Stephen F TraynelisRay Dingledine
Jul 29, 2011·Journal of Neurophysiology·Wanhua ShenHollis T Cline
Sep 25, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brett L BenedettiAlison L Barth
May 15, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·J Julius Zhu
May 12, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Eun Jeong LimHeung Sik Na
Mar 3, 2007·Molecular and Cellular Neurosciences·Michael I DawJohn T R Isaac
May 23, 2013·Journal of Neurochemistry·Yuniesky Andrade-TalaveraAntonio Rodríguez-Moreno
Mar 13, 2014·Cerebral Cortex·Alex Crocker-BuqueMichael I Daw
Sep 6, 2007·Neuron·Camilla Bellone, Roger A Nicoll
Jan 19, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Melis Inan, Michael C Crair
Jun 23, 2012·Journal of Neurophysiology·Angel NuñezDavid Fernández de Sevilla
Oct 21, 2006·Biochemical Society Transactions·J R Mellor

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