PMID: 15228184Jul 2, 2004Paper

Rapid alleviation of signs and symptoms of rheumatoid arthritis with intravenous or subcutaneous administration of adalimumab in combination with methotrexate

Scandinavian Journal of Rheumatology
Rolf RauH Kupper

Abstract

This randomized, placebo-controlled, double-blind, Phase 1 study assessed the magnitude, onset, and duration of response with intravenous (i.v.) and subcutaneous (s.c.) adalimumab (Humira, Abbott Laboratories) combined with methotrexate (MTX) in patients with active rheumatoid arthritis (RA) despite previous MTX therapy. Fifty-four patients were randomized to two injections of i.v. or s.c. adalimumab (1 mg/kg) or placebo while continuing on MTX (mean dose, 15.7 mg/week). Dosing intervals were determined by the European League Against Rheumatism (EULAR) response criteria, and were allowed to range from 1 to 3 months. Efficacy was mainly assessed using the EULAR response criteria and the American College of Rheumatology (ACR) response criteria. Moderate EULAR response was achieved at least once within 29 days after the first injection in 83% and 61% of patients receiving i.v. and s.c. adalimumab respectively, compared with 44% for placebo [probability (p) < or = 0.05 for i.v. adalimumab versus placebo]. A 20% improvement in disease activity according to the ACR criteria (ACR20 response) was achieved by 72% and 67% of patients receiving i.v. and s.c. adalimumab respectively, compared with 28% for placebo (p < or = 0.01 and p < or ...Continue Reading

References

Feb 13, 2002·Arthritis and Rheumatism·UNKNOWN American College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines

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Citations

Apr 19, 2008·BMC Musculoskeletal Disorders·Alberto Alonso-RuizAntonio Quintana
Sep 17, 2005·Pharmacotherapy·David J Rychly, Joseph T DiPiro
Jan 24, 2008·International Journal of Dermatology·Sharon E JacobFrancisco A Kerdel
Aug 24, 2006·Expert Opinion on Pharmacotherapy·Bart J F van den BemtRob Janknegt
Nov 2, 2012·BMC Musculoskeletal Disorders·Liseth SiemonsMart Afj Van de Laar
Feb 18, 2011·The Cochrane Database of Systematic Reviews·Jasvinder A SinghRachelle Buchbinder
May 10, 2017·The Cochrane Database of Systematic Reviews·Jasvinder A SinghGeorge A Wells
Jul 22, 2005·The Cochrane Database of Systematic Reviews·F Navarro-SarabiaI Villanueva

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