Abstract
The development and use of a fast method employing a direct analysis in real time (DART) ion source coupled to high-resolution time-of-flight mass spectrometry (TOFMS) for the quantitative analysis of caffeine in various coffee samples has been demonstrated in this study. A simple sample extraction procedure employing hot water was followed by direct, high-throughput (<1 min per run) examination of the extracts spread on a glass rod under optimized conditions of ambient mass spectrometry, without any prior chromatographic separation. For quantification of caffeine using DART-TOFMS, an external calibration was used. Isotopically labeled caffeine was used to compensate for the variations of the ion intensities of caffeine signal. Recoveries of the DART-TOFMS method were 97% for instant coffee at the spiking levels of 20 and 60 mg/g, respectively, while for roasted ground coffee, the obtained values were 106% and 107% at the spiking levels of 10 and 30 mg/g, respectively. The repeatability of the whole analytical procedure (expressed as relative standard deviation, RSD, %) was <5% for all tested spiking levels and matrices. Since the linearity range of the method was relatively narrow (two orders of magnitude), an optimization of ...Continue Reading
References
Jan 1, 1997·Plant Foods for Human Nutrition·M U EtengC Y Aremu
Nov 24, 1999·Journal of Agricultural and Food Chemistry·M CzernyW Grosch
Oct 16, 2004·Science·Zoltán TakátsR Graham Cooks
Apr 15, 2005·Analytical Chemistry·Robert B CodyH Dupont Durst
Dec 1, 2005·Analytical Chemistry·Charles N McEwenBarbara S Larsen
Jul 10, 2008·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·L La PeraG Dugo
Jun 2, 2009·Analytica Chimica Acta·Lukas VaclavikJana Hajslova
Jan 6, 2010·Journal of Agricultural and Food Chemistry·Roman KubecEric Block
Sep 30, 2010·Talanta·Lukas VaclavikJana Hajslova
Dec 16, 2010·Rapid Communications in Mass Spectrometry : RCM·Sara E EdisonKai Zhang
Apr 30, 2011·Journal of Agricultural and Food Chemistry·Lukas VaclavikJana Hajslova
Oct 15, 2008·Food Chemistry·Daniel PerroneAdriana Farah
Citations
Aug 6, 2013·Analytical and Bioanalytical Chemistry·Sonja KriegerOliver J Schmitz
Sep 17, 2013·Analytical and Bioanalytical Chemistry·Jürgen H Gross
Jan 11, 2013·Chemical Reviews·María Eugenia MongeFacundo M Fernández
Jun 27, 2014·ISRN Nutrition·Abdulmumin A Nuhu
Jul 30, 2014·Analytical and Bioanalytical Chemistry·Anastasia AlbertCarsten Engelhard
Feb 18, 2016·Journal of the American Society for Mass Spectrometry·Joel D KeelorFacundo M Fernández
Sep 10, 2015·Rapid Communications in Mass Spectrometry : RCM·Matthew CurtisFacundo M Fernández
Mar 24, 2016·Analytical and Bioanalytical Chemistry·Domenico TavernaFabio Mazzotti
Dec 18, 2013·Mass Spectrometry Reviews·Xuelu Ding, Yixiang Duan
May 16, 2015·Mass Spectrometry Reviews·Tianyang GuoTianwei Tan
Jun 9, 2016·Mass Spectrometry Reviews·Matthew J PavlovichAdam B Hall
Jul 19, 2016·Rapid Communications in Mass Spectrometry : RCM·Samantha Barry, Jean-Claude Wolff
Jul 31, 2016·Journal of Analytical Toxicology·Justin L PoklisMichelle R Peace
May 20, 2015·Mass Spectrometry Reviews·Marek SmoluchJerzy Silberring
May 8, 2019·Rapid Communications in Mass Spectrometry : RCM·Tijana VasiljevicJanusz Pawliszyn
Jun 13, 2017·Journal of Forensic Sciences·Sara E KernDouglas T Heitkemper
Sep 4, 2019·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Wendy C AndersenMark Madson
Sep 25, 2020·Scientific Reports·Yuzhou GuiGangyi Liu
Jun 5, 2014·European Journal of Mass Spectrometry·Jürgen H Gross
Dec 6, 2020·Rapid Communications in Mass Spectrometry : RCM·Xiaoping ZhangKonstantin Chingin
Feb 13, 2021·Foods·Cláudia P PassosManuel A Coimbra
May 1, 2021·Foods·Nerea NúñezOscar Núñez
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nuntouchaporn HutachokSomdet Srichairatanakool