Rapid and complicated HIV genotype expansion among high-risk groups in Guangdong Province, China

BMC Infectious Diseases
Ping-Ping ZhouX He

Abstract

Guangdong Province is one of the most developed and populous provinces in southern China, with frequent foreign exchanges and large transient population. The annual number of cases of HIV/AIDS reported in Guangdong has been higher than most of provinces in China for several successive years. HIV infection by heterosexual transmission occurs across the province, with transmission among men who have sex with men occurring mainly in larger urban centers. There is a lack of widespread and representative data on the distribution of HIV subtypes in Guangdong. This study aimed to thoroughly investigate and estimate the prevalence and distribution of HIV-1 subtypes using a city-based sampling strategy to better understand the characteristics of HIV transmission in Guangdong. Archived plasma samples (n = 1205) from individuals diagnosed as HIV-1 infection in 2013 were selected randomly from all 21 cities in Guangdong Province. Genotypes were determined using env and/or gag sequences using phylogenetic analysis. The distributions of HIV genotypes in different risk groups and different cities were analyzed. A total of 15 genotypes, including six discordant genotypes, were identified. The four main HIV-1 subtypes in Guangdong were CRF01_AE...Continue Reading

References

Nov 1, 1995·AIDS Research and Human Retroviruses·A C SiepelB T Korber
Jul 10, 2016·AIDS Research and Human Retroviruses·Xin ChenYong-Tang Zheng
Aug 9, 2017·Sexually Transmitted Infections·Xiaoshan LiPingmin Wei
Nov 22, 2017·Infectious Diseases of Poverty·Men-Bao QianXiao-Nong Zhou

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Citations

Apr 18, 2020·The Journal of Antimicrobial Chemotherapy·Yun LanFengyu Hu
Sep 3, 2020·AIDS Research and Human Retroviruses·Yun LanFengyu Hu
Nov 30, 2019·AIDS Research and Human Retroviruses·Bingyu LiangLi Ye
Jan 2, 2020·International Journal of Environmental Research and Public Health·Xiaojun ZhangZhiqiang Wang
Dec 15, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Yun LanFengyu Hu

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Methods Mentioned

BETA
RIP
genotyping
PCR

Software Mentioned

HIVAlign
Excel
MEGA
BioEdit

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