Rapid and selective extraction of multiple macrolide antibiotics in foodstuff samples based on magnetic molecularly imprinted polymers

Talanta
Yusun ZhouYong-Ill Lee

Abstract

Magnetic molecularly imprinted polymers (MMIPs) were prepared based on surface molecular imprinting using erythromycin (ERY) as template molecule and Fe3O4 nanoparticles as support substrate. The MMIPs possessed high adsorption capacity of 94.1 mg/g for ERY and the imprinting factor was 11.9 indicating good imprinted effect for ERY. Selective evaluation demonstrated favorable selectivity of MMIPs for multiple macrolide antibiotics (MACs). Using MMIPs as adsorptive material, a rapid and convenient magnetic solid-phase extraction (MSPE) procedure was established for simultaneous and selective separation of six MACs in pork, fish and shrimp samples, then the MACs was subjected to high-performance liquid chromatography-ultraviolet (HPLC-UV) analysis. At different fortified concentrations, the extraction recoveries could reach 89.1% and the relative standard deviations were lower than 12.4%. Chromatogram revealed the response signals of MACs in spiked samples were greatly enhanced and matrix interferences were effectively eliminated after treatment with MSPE. The proposed MSPE procedure coupled with HPLC-UV realized selective and sensitive determination of multiple MACs in foodstuff samples.

References

Mar 23, 2001·Journal of Chromatography. a·C LealM D Prat
Nov 2, 2005·Advanced Drug Delivery Reviews·David A Spivak
Nov 17, 2006·Journal of Biochemical and Biophysical Methods·Chiyang HeFeng Liu
Apr 26, 2007·Analytica Chimica Acta·Claudio BaggianiCristina Giovannoli
Jun 15, 2007·Analytical and Bioanalytical Chemistry·Chau Jin Tan, Yen Wah Tong
Mar 28, 2008·Analytical and Bioanalytical Chemistry·Suquan SongDabing Zhang
Feb 13, 2010·The Annals of Pharmacotherapy·Joshua D CourterJennifer E Girotto
Aug 4, 2010·Analytica Chimica Acta·K Aguilar-ArteagaE Barrado
Sep 11, 2010·Biosensors & Bioelectronics·Tao JingYikai Zhou
Apr 19, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Zhaohui ZhangShouzhuo Yao
Oct 22, 2011·International Journal of Molecular Sciences·Giuseppe VasapolloGiuseppe Mele
Dec 6, 2011·Chemical Communications : Chem Comm·Xiantao ShenHeqing Tang
Jan 6, 2012·Chemical Communications : Chem Comm·Wei ZhangYu-Kui Zhang
Jul 11, 2012·Journal of Chromatography. a·Fang-Fang ChenYan-Ping Shi
Sep 27, 2012·Dermatitis : Contact, Atopic, Occupational, Drug·Viba MalaiyandiSandy Skotnicki-Grant
Mar 30, 2013·Journal of Chromatographic Science·Ling-Xiao YiGuan-Hua Chen
Feb 26, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Franziska JanuschGerd Hamscher

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Citations

Mar 5, 2016·Chemical Society Reviews·Lingxin ChenJinhua Li
May 22, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Qian TangCheuk-Fai Chow
Jul 20, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yan-Fei WangWei-Jian Wu
Apr 14, 2018·Analytical and Bioanalytical Chemistry·Shuyao HuangGangfeng Ouyang
Sep 25, 2018·Chemical Reviews·Joseph J BelBruno

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