Rapid and selective mobilization of specific stem cell types after consumption of a polyphenol-rich extract from sea buckthorn berries (Hippophae ) in healthy human subjects

Clinical Interventions in Aging
Christian DrapeauGitte S Jensen

Abstract

The aim of this study was to evaluate the effects of a proanthocyanidin-rich extract of sea buckthorn berry (SBB-PE) on the numbers of various types of adult stem cells in the blood circulation of healthy human subjects. A randomized, double-blind, placebo-controlled, cross-over trial was conducted in 12 healthy subjects. Blood samples were taken immediately before and at 1 and 2 hours after consuming either placebo or 500 mg SBB-PE. Whole blood was used for immunophenotyping and flow cytometry to quantify the numbers of CD45dim CD34+ CD309+ and CD45dim CD34+ CD309- stem cells, CD45- CD31+ CD309+ endothelial stem cells, and CD45- CD90+ mesenchymal stem cells. Consumption of SBB-PE was associated with a rapid and highly selective mobilization of CD45dim CD34+ CD309- progenitor stem cells, CD45- CD31+ CD309+ endothelial stem cells, and CD45- CD90+ lymphocytoid mesenchymal stem cells. In contrast, only minor effects were seen for CD45dim CD34+ CD309+ pluripotential stem cells. Consumption of SBB-PE resulted in selective mobilization of stem cell types involved in regenerative and reparative functions. These data may contribute to the understanding of the traditional uses of SBB for preventive health, regenerative health, and postp...Continue Reading

Citations

Jan 2, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·B MarciniakA Stochmal
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Oana-Viorela NistorNicoleta Stănciuc

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Methods Mentioned

BETA
blood draw
flow cytometry
blood draws

Clinical Trials Mentioned

NCT03388073

Software Mentioned

Excel
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