Rapid and simplified method for the analysis of polychloronaphthalene congener distributions in environmental and human samples by gas chromatography coupled to negative ion chemical ionization mass spectrometry

Journal of Chromatography. a
Daniel Carrizo, Joan O Grimalt

Abstract

A method for the analysis of congener-specific polychloronaphthalene mixtures in sediments and human sera based on combined applications of gas chromatography coupled to negative ion chemical ionization mass spectrometry (GC-NICI-MS) is described. Separation, identification and quantification of the constituent congeners is achieved in both types of samples. Besides the octa- and heptachloronaphthalenes the method allows the identification of 9 hexachloronaphthalene congeners, 12 pentachloronaphthalenes and 8 tetrachloronaphthalenes. Detection and quantification limits were in the order of 0.4-0.7 ng g-1 dry weight and 0.9-1.3 ng g-1 dry weight in sediments, respectively, and 0.06-0.11 ng mL-1 and 0.18-0.21 ng mL-1 in human sera, respectively. Application of the method to study the distributions of these compounds nearby a chlor-alkali plant located at the shore of the Ebro River has shown that whereas the most chlorinated compounds, octachloronaphthalene and the two heptachloronaphthalenes were dominant in the sediments, tri-, tetra-, penta- and hexachloronaphthalenes were the most abundant congeners found in human sera.

References


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Citations

Jul 24, 2013·Analytical and Bioanalytical Chemistry·Paul BendigWalter Vetter
Aug 25, 2007·Journal of the American Society for Mass Spectrometry·Jianxun ZhangYinlong Guo
Jul 22, 2015·Environmental Science and Pollution Research International·Shunji HashimotoYasuyuki Shibata
Apr 8, 2011·International Journal of Epidemiology·Mònica GuxensUNKNOWN INMA Project
May 18, 2010·Journal of Environmental Monitoring : JEM·Xiaohui PanGan Zhang
Jan 31, 2007·Journal of Mass Spectrometry : JMS

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