Rapid and simultaneous determination of nonsteroidal anti-inflammatory drugs in human plasma by LC-MS with solid-phase extraction

Analytical and Bioanalytical Chemistry
Koichi SuenamiSusumu Kanno

Abstract

A rapid, selective and sensitive analytical method for the simultaneous determination of 16 nonsteroidal anti-inflammatory drugs (NSAIDs) in human plasma was carried out using Oasis HLB solid-phase extraction (SPE), followed by reversed-phase high-performance liquid chromatography and quadrupole mass spectrometry with electrospray ionization operated in the negative ion mode. The recoveries of NSAIDs from human plasma by SPE were greater than 76.7%. The use of a short column packed with small particles enabled rapid and simultaneous determination within 7 min. The detection limits for the NSAIDs were 0.01-0.9 mug/ml using the selected ion monitoring mode.

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Citations

Aug 19, 2009·Analytical and Bioanalytical Chemistry·Alejandro Lapresta-FernándezGerhard J Mohr
Jul 4, 2012·Journal of Fluorescence·J A Murillo PulgarínF Martínez Ferreras
Apr 26, 2012·Journal of Chromatographic Science·Najma SultanaAgha Zeeshan Mirza
Sep 17, 2013·Journal of Pharmaceutical and Biomedical Analysis·Tetsuya NemotoKeizo Sato
Apr 1, 2014·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Hyung Joo KimWoo Seong Kim
May 27, 2016·Journal of Separation Science·Yongqin LvFrantisek Svec
Sep 15, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Koichi SuenamiSusumu Kanno
Feb 20, 2007·Journal of Separation Science·Koichi SuenamiSusumu Kanno
Jan 3, 2007·Journal of Mass Spectrometry : JMS
Dec 2, 2020·Environmental Pollution·Parnian IzadiSatinder Kaur Brar

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