Rapid Automated Quantification of Cerebral Leukoaraiosis on CT Images: A Multicenter Validation Study

Radiology
Liang ChenIST-3 Collaborative Group

Abstract

Purpose To validate a random forest method for segmenting cerebral white matter lesions (WMLs) on computed tomographic (CT) images in a multicenter cohort of patients with acute ischemic stroke, by comparison with fluid-attenuated recovery (FLAIR) magnetic resonance (MR) images and expert consensus. Materials and Methods A retrospective sample of 1082 acute ischemic stroke cases was obtained that was composed of unselected patients who were treated with thrombolysis or who were undergoing contemporaneous MR imaging and CT, and a subset of International Stroke Thrombolysis-3 trial participants. Automated delineations of WML on images were validated relative to experts' manual tracings on CT images, and co-registered FLAIR MR imaging, and ratings were performed by using two conventional ordinal scales. Analyses included correlations between CT and MR imaging volumes, and agreements between automated and expert ratings. Results Automated WML volumes correlated strongly with expert-delineated WML volumes at MR imaging and CT (r2 = 0.85 and 0.71 respectively; P < .001). Spatial-similarity of automated maps, relative to WML MR imaging, was not significantly different to that of expert WML tracings on CT images. Individual expert WML ...Continue Reading

References

Dec 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·J C van SwietenJ van Gijn
Oct 26, 1999·IEEE Transactions on Medical Imaging·D RueckertD J Hawkes
Jun 2, 2001·Stroke; a Journal of Cerebral Circulation·L O WahlundUNKNOWN European Task Force on Age-Related White Matter Changes
Dec 7, 2002·Stroke; a Journal of Cerebral Circulation·Leonardo PantoniDomenico Inzitari
Jul 2, 2003·International Journal of Geriatric Psychiatry·R RielloG B Frisoni
Dec 2, 2004·Dementia and Geriatric Cognitive Disorders·Roberta RossiGiovanni B Frisoni
Jul 23, 2013·Lancet Neurology·Joanna M WardlawUNKNOWN STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1)
Apr 23, 2014·Neurocritical Care·Nils HenningerSusanne Muehlschlegel
May 13, 2014·NeuroImage. Clinical·Céline R GillebertDante Mantini
May 23, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·P BentleyC Beckmann
Jun 18, 2014·NeuroImage. Clinical·Paul BentleyDaniel Rueckert
Sep 23, 2014·The Psychiatric Bulletin·Tarun KuruvillaIain Lyburn
Sep 23, 2014·The Psychiatric Bulletin·Mustafa Alachkar
Jan 19, 2015·Medical Image Analysis·Christian LedigDaniel Rueckert
Apr 30, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Lasse WillerHanne Christensen
Feb 18, 2016·International Journal of Stroke : Official Journal of the International Stroke Society·Christian HerwehSimon Nagel
Jun 15, 2016·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Nerses SanossianJeffrey L Saver
Aug 6, 2016·Stroke; a Journal of Cerebral Circulation·Andreas CharidimouNatalia Rost
Dec 23, 2016·Brain : a Journal of Neurology·Wi-Sun RyuDong-Eog Kim

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Citations

May 1, 2019·Neurological Research·Hamidreza SaberDavid S Liebeskind
Oct 28, 2018·Neurology·Grant MairUNKNOWN IST-3 Collaborative Group
Nov 2, 2019·Japanese Journal of Radiology·Yuki ShinoharaToshibumi Kinoshita
Nov 12, 2019·Frontiers in Physiology·Muzaimi MustaphaMazira Mohamad Ghazali
Jul 17, 2020·Nature Reviews. Neurology·Monika A MyszczynskaLaura Ferraiuolo
Jul 21, 2021·Expert Review of Neurotherapeutics·Giuseppe CorriasLuca Saba
Oct 9, 2021·AJNR. American Journal of Neuroradiology·A MahammediA Vagal
Dec 20, 2018·Lancet Neurology·Carol Brayne

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