PMID: 1986984Jan 1, 1991Paper

Rapid baroreceptor resetting in chronic hypertension. Implications for normalization of arterial pressure

Hypertension
P L XieF M Abboud

Abstract

The purpose of this study was to examine the ability of baroreceptors of renal hypertensive rabbits to reset rapidly during acute changes in arterial pressure. The carotid sinus (CS) was vascularly isolated and baroreceptor activity was recorded during slow ramp increases in CS pressure in hypertensive (one-kidney, one wrap; 127 +/- 3 mm Hg) and normotensive (one-kidney, no wrap; 85 +/- 3 mm Hg) rabbits anesthetized with chloralose. Control measurements were made after holding pressure for 10-15 minutes at the level of arterial pressure recorded before each experiment. Baroreceptor threshold pressure (Pth) was higher in hypertensives (78 +/- 4 mm Hg) compared with normotensives (55 +/- 3 mm Hg, p less than 0.05), and nerve activity was less in hypertensives over a wide range of pressure. CS distensibility (sonomicrometers) was not significantly different in the two groups. After increasing holding pressure from control by 30 and 60 mm Hg for 10-15 minutes, the extent of baroreceptor resetting (delta Pth/delta holding pressure x 100%) in normotensives was 39 +/- 6% and 33 +/- 2%, respectively, but only 14 +/- 5% and 9 +/- 3% in hypertensives (p less than 0.05). After decreasing holding pressure by 30 and 60 mm Hg, resetting was ...Continue Reading

References

Mar 1, 1976·The American Journal of Physiology·H N Sapru, S C Wang
Feb 1, 1990·Hypertension·E D MoreiraE M Krieger
Apr 1, 1988·The American Journal of the Medical Sciences·M W ChapleauF M Abboud
Mar 1, 1968·Acta Physiologica Scandinavica·H Aars
May 21, 1934·The Journal of Physiology·R T Grant, P Rothschild

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Citations

Jul 22, 1998·Journal of the Autonomic Nervous System·Q H ChenH Kosaka
Nov 23, 2012·Journal of Neuroscience Research·Anke Vermehren-SchmaedickAgnieszka Balkowiec
Jul 29, 2006·Autonomic Neuroscience : Basic & Clinical·Pedro Dall'agoMaria Cláudia Irigoyen
Jan 29, 2017·Expert Opinion on Pharmacotherapy·Yogita RochlaniWilbert S Aronow
Jan 20, 2017·Current Hypertension Reports·Ayhan YorukJohn D Bisognano
Aug 1, 1995·Hypertension·M W ChapleauF M Abboud
Jan 14, 1999·Journal of Applied Physiology·H E GreenbergS M Scharf

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